ONLINE NOW: Two new somatic mutation studies in #liver disease from CRI's Hao Zhu Lab: 🟠Journal of Hepatology w/ postdoc Qiyu Zeng, Ph.D. journal-of-hepatology.eu/article/S0168-… 🟠Journal of Clinical Investigation w/ grad student Greg Mannino jci.org/articles/view/… 🔖🧵 Hao's thread ⬇️

🤯 in Cell An alternate receptor for adeno-associated viruses cell.com/cell/fulltext/… carboxypeptidase D [CPD] is an alternate AAV receptor- totally explains why AAV8 vectors are SO efficient at pancreatic exocrine cell transduction for CRISPR engineering.

Our #SomaticGenomics platform follows a novel approach to uncovering links between genes and disease. This reveals a path to develop transformative therapeutics with intrinsically validated targets. Discover how our platform works: bit.ly/3AkWg71

Always proud of my brilliant colleague, collaborator, friend Hsieh Lab who received the prestigious bladder Ca research innovation Bladder Cancer Advocacy Network award! We keep working to advance the field! Fred Hutch Cancer Center Dr. Tom Lynch Nicole D. Fleming MD Rahul Banerjee, MD, FACP OncoAlert Dr. Bishoy M. Faltas

Thank you Cancer Research for selecting our story for the cover this month (art credit: Jose Cabrera)!

When the reviewers' identities are revealed

Our latest paper is out in Hepatology. We found that aging causes loss of the unique organization and communication of the cells of the liver. It may inform the development of new therapies targeting age-associated liver dysfunction. news.weill.cornell.edu/news/2025/07/s…

Major congrats to First author Saloni Sinha who help to lead this project in the lab. We surprisingly found that hepatic zonation is very perturbed and altered and there is development of cells with aberrant gene expression during aging. #Liver #LiverDisease

Congratulations to Justin Engel, Ph.D. student, on receiving the 2025 Nominata Award—UTSW’s highest graduate student honor—for his groundbreaking research on chromothripsis and its role in tumor growth and therapy resistance. Learn more: bit.ly/4kvD8EL #UTSWEdu

Fascinating & important Cell paper from Helmholtz Munich | @HelmholtzMunich Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia cell.com/cell/fulltext/… A study that links deregulation of the hepatic circadian clock with peripheral tissue wasting.

How do cells organize six feet of DNA in a tiny nucleus? Huabin Zhou, Ph.D., a postdoctoral fellow in the Rosen Lab, is uncovering the answer and just earned the 2025 Brown-Goldstein Award for his work on chromatin structure and biomolecular condensates. bit.ly/4lGmxzm

Great move by AACR, providing a research manuscript automatically sent for external peer review for reviewers of at least 3 manuscripts on AACR journals. I hope more journals will consider this incentive. The current model of solely kindness-based peer review is unsustainable.

⚡️Thrilled that #VirtualLab is published in nature! nature.com/articles/s4158… We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.

ONLINE NOW in nature Metabolism: latest #relentlessdiscovery from CRI's DeBerardinis Lab full 🧵 on Blue Sky ➡️ bsky.app/profile/rjdlab… Paper ⬇️ nature.com/articles/s4225…