🚨preprint alert🚨 We report a #GWAS with ratios between protein levels from the Olink Proteomics Explore 1536 #proteomics data from ~54,000 participants of the UK Biobank using the DNAnexus, Inc. platform. biorxiv.org/content/10.110… 1/13

Case-control GWAS on 11m variants in 335k people in <4 mins using ONLY summary-level data! Check out our isGWAS bioRxiv at biorxiv.org/content/10.110… - large multi GWAS now accessible to all! Made possible with MarioniGroup Heiko Runz Zhana & Chris Foley!

Proteomics outshines polygenic risk scores in predicting 218 common and rare diseases. Impressive C-statistics for some diseases for which we have few predictive tools in the clinic. omicscience on a roll with Robert Scott @pietznerm and others medrxiv.org/content/10.110…

Anyone who wants to study #HLA but feels hesitant as HLA is too complicated☹️? Happy to share our paper Nature Protocols describing the up-to-date knowledge on HLA #genetics and step-by-step tutorial for HLA imputation and association with Soumya Raychaudhuri সৌম্য রায়চৌধুরী🥳 nature.com/articles/s4159…

A genome-wide meta-analysis of data from 6 US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of depression Anders Børglum nature.com/articles/s4159…

This macrophage tattoo is made of macrophages! Have you ever wondered why tattoos are permanent? In tattooing, ink is injected into the skin. Some of this ink is expelled with the epidermis o, but the rest remains in the dermis for life. 🧵1/10

New research from Sergio Villicaña Jordana Bell & co. King's College London, with findings that improve the characterisation of the mechanisms underlying DNA methylation variability & are informative for prioritisation of GWAS variants for functional follow-ups bit.ly/3qh5pJi

This is as close as our group could get to a how-to guide for studies of the environment and #epigenetics Don't forget DNA sequence variation. Look for transcription factor and cell signalling effects. @_jjdubs David A Knowles (@davidaknowles.bsky.social) Sri Raj journals.plos.org/plosgenetics/a…

The “unknome” database ranks human proteins by how little we know about them. sciencenews.org/article/unknom…

RNAseq counting tools are not perfect. I simulated 240 GTEx samples to test multiple tools. Below I show the difference between actual and estimated counts for each simulated sample. But, what is causing this? And will it affect differential expression? (1/7) #Bioinformatics

🆕 nature A major genomic sequencing feat finally accomplished: a complete, gapless map of the human Y-chromosome, a notoriously difficult palindrome and repeat-laden region, with discovery of 41 new genes nature.com/articles/s4158…

Excited to share our work introducing a remarkably efficient approach to model linkage disequilibrium, now published in Nature Genetics nature.com/articles/s4158… This work was led by Pouria Salehi Nowbandegani and @WilderWohns

Huge congrats to our HST Harvard Medical School student Jiwoo Lee using Mendelian randomization to estimate healthcare costs attributed to various clinical risk factors. Highlights substantial estimated cost savings from treating obesity nature.com/articles/s4146… Nature Communications Andrea ganna

Five steps to connect genetic risk variants to disease nature.com/articles/d4158… #journals #feedly

Obesity rate by country from 1990 to today, for selected countries. Time to study what France is doing right! #dataviz source: reddit.com/r/dataisbeauti…

Quick thread on the Astra Zeneca (AZ) covid vaccine since it's been in the news today. TLDR there isn't a new "smoking gun", the AZ vax was one of first and cheapest, it saved millions of lives globally, there are better vax out there now, adapted to new variants 1/9

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca

Very happy to present our new paper led by an excellent team of graduate students Michael Slobodyanyuk Alec Bahcheli at Ontario Institute for Cancer Research (OICR) Department of Molecular Genetics, U of T Medical Biophysics: nature.com/articles/s4146… 1/4

Shotgun metagenomics data for >200 healthy Asian octogenerians helped us identify key gut microbial hallmarks of healthy aging, including some that are only consistently seen in Asian cohorts! 4 Major results in thread #aging #microbiome biorxiv.org/content/10.110…

Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in nature today studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,