New research from Veronika Pak Iturria-Medina & colleagues describes how the human brain distribution of canonical cell types predicts tissue damage in 13 neurodegenerative conditions (including #Parkinsons); Strong mediating role for microglia & astrocytes elifesciences.org/articles/89368

The Commons Cell Atlas is an open data project. All the raw data (FASTQs) are available, including the notebooks for pre-processing them and assembling a whole atlas. Want a variant of our Human CCA? Just clone the repo. 17/

#singlecellgenomicsday

📣Article out! Novel personalized whole-brain neural-mass models, adding spatial amyloid & tau, to assess synergistic impact on functional activity in Alzheimer’s. From fMRI, AB/Tau PET, to realistic excitabilities and impact on blood markers & cognition👉rdcu.be/dGQM6

Check out Integrated Prgrm. in Neuroscience MSc. student Veronika Pak's Neuroblog on "Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions"! McGill University The Neuro Research Institute of the MUHC (The Institute) #Montreal #neuroscience mcgill.ca/.../ipn.../ver…

Powerful, beautiful #poetry reminding us why we honor and support our loved ones as they face frailty of mind and body. #Alzheimers #dementia

Correlation is not causation. In our new perspective, we connect systems biology, causal reasoning, and machine learning to inform future approaches in systems biology and molecular medicine in the wake of current deep learning advances: doi.org/10.1038/s44320… 🧵👇

1/ 10 courses to get you started with bioinformatics 🧵

Learning from single-cell RNA-seq of 1.3 million brain cells from 16 individuals with #Alzheimers disease and 32 controls. Potential protective of Reelin and choline intake/supplementation nature.com/articles/s4158… Manolis Kellis Mathys Lab Carles Boix @DrLiHueiTsai and

Thrilled to share Fabian Theis lab paper on transformers in single cell omics out in Nature Methods ! Check it out to learn about the latest models, how they are trained, applied, and their limitations. rdcu.be/dQuVW (🧵1/7)

Just published! Check out our study of early immunoediting in breast cancer tumors, led by Dr. Ying Zhang and myself, from Lieberman and Hide (@winhide) laboratories. Paper link: rdcu.be/dRys2 nature.com/articles/s4159… Nature Immunology Read more below (1/6):

Never before a study compared white matter hyperintensities in so many dementias and so many patients (N=4549). Here we assessed correlations with atrophy, Alzheimer biomarkers and cognitive performance. Of course, we put the focus on dementia with Lewy bodies 👇👇👇

Our extensive Review of multi-scale and multi-factorial computational models in the search for neurodegenerative disease mechanisms and precise treatments, out in TranslationalPsychiatry👉 rdcu.be/dUNk2. Last PhD article from Ahmed Faraz Khan

A nice news piece from Alzforum covering our latest paper. 🙏🏼 Marc Aurel Busche for pitching in! Synaptic Skirmish: Aβ and Tau Pathologies Battle Over Brain Rhythms alzforum.org/news/research-…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

@lemwisse and I are involved in a super cool project to advance our ability to measure spatially-resolved omics data from human tissue. We are looking for a postdoc to help push this project forward. Details below! RT appreciated!! fens.org/careers/job-ma…

A fascinating new study just published online today in Nature Medicine reports an extraordinary case of an individual carrying the PSEN2 (p.Asn141Ile) mutation—a known driver of dominantly inherited Alzheimer’s disease (DIAD)—who remained cognitively healthy well into his

‼️PhD Position now available in my lab‼️ Do you like: * Neurodegenerative disease? * Neuroimaging and/or multi-omics? * AI and data-driven life science? Want to work with RikOssenkoppele Alexandra Young and Laura Wisse? Apply here: lu.varbi.com/what:job/jobID… Please rt/share 🙏