📍#BrainStorm (NCT04109131), an investigator-initiated prospective #ClinicalStudy recruiting in 🇧🇪🇫🇷🇱🇺 to better understand #epidemio & #biology of 🧠 metastases 🗞 Hot off the press our correspondence to Nature Medicine explaining design&objectives 👉tinyurl.com/BrainStormStudy 🧵

I suspect that Andrew Ng and Yann LeCun have missed the main reason why the big companies want regulations. Years ago the founder of a self-driving company told me that he liked safety regulations because if you satisfied them it reduced your legal liability for accidents.

More clinical innovation: Longitudinal cerebrospinal fluid liquid biopsy in phase 0/2 trial of niraparib for newly-diagnosed glioblastoma. Saturday, 10:55 AM – 11:05 AM. Room 118-120. #SNO2023

Norbert Galldiks Jan-Michael Werner Congrats! We need biomarkers to predictive regorafenib efficacy!

Missing Data Imputation with High-Dimensional Data. Alberto Brini & Edwin R. van den Heuvel. The American Statistician. tandfonline.com/doi/full/10.10…

Staggering how many excellent healthcare researchers refuse to engage with prediction models that present risk estimates. They rather push for classification or tests, even when they agree patient decisions are based on risk judgements & that risk thresholds vary ...

Yann LeCun thinks the risk of AI taking over is miniscule. This means he puts a big weight on his own opinion and a miniscule weight on the opinions of many other equally qualified experts.

15 years after a giant leap for cancer genomics. #CancerGenomics nature #NewsAndViews nature.com/articles/d4158…

CurveCurator: a recalibrated F-statistic to assess, classify, and explore significance of dose–response curves | Nature Communications nature.com/articles/s4146… #Bioinformatics

🎤 #OncologyGrandRounds: A comprehensive review and update of the current treatment landscape for platinum-resistant #OvarianCancer. ➡️ brnw.ch/21wEZjj #gyncsm #ImmunoOnc #ADC Jess St. Laurent

baymedr: an R package and web application for the calculation of Bayes factors for superiority, equivalence, and non-inferiority designs. Maximilian Linde & Don van Ravenzwaaij. BMC Medical Research Methodology volume 23, Article number: 279 (2023). bmcmedresmethodol.biomedcentral.com/articles/10.11…

#RealityCentricAI means real-world applications: Patients might experience adverse events during their time under care. Timely outcome prediction is essential to detect & intervene early! In our #NeurIPS2023 paper, Yuchao Quin, Changhee Lee & I propose a novel method: RAS!

ReConPlot: an R package for the visualization and interpretation of genomic rearrangements academic.oup.com/bioinformatics…

A new #DoctorWho episode shown during the festive period, especially on Christmas Day, is associated with lower death rates in the subsequent year across the UK, finds new #ChristmasBMJ study #DrWho Richard Riley (R²) bmj.com/content/383/bm…

A simple nudge such as placing a chair at a patient’s bedside can increase a physician’s likelihood to sit by 20-fold, finds study, which also improves patients’ perceptions of their physician 👍🏽 Study includes a #VisualAbstract #BMJChristmas bmj.com/content/383/bm…

⭐️NEW paper “Clinical prediction models and the multiverse of madness” For any model created, a multiverse of other potential models exists & an individual’s prediction may vary greatly across this multiverse Avengers endgame: examine this instability🙏 bmcmedicine.biomedcentral.com/articles/10.11…

An excellent medical student assessed the clinical usefulness of 600 RCTs in child health. Things are improving but more work is needed on making them more patient centered. Assessment of Usefulness of Randomized-Control Trials in Child Health ... sciencedirect.com/science/articl…

#OnlineFirst: Genetic characterization and mutational profiling of foramen magnum meningiomas: a multi-institutional study. thejns.org/view/journals/….

Complete takedown of Devin.

Just out, led by Adam Khan, we assess risk, benefit and outcomes in one decade of Ramucirumab trials The overall survival gain across this decade was 1.5 months The amount of harm to patients and misuse of participants is staggering Thoughts 🧵 dx.doi.org/10.1002/cam4.7…