1/15 Ever wonder why metronidazole (Flagyl) treats both bacteria and parasites? The answer may also explain the infamous disulfiram-like reaction that can occur when metronidazole is mixed with alcohol. #tweetorial #medtwitter

Our single-nucleus cross-tissue cell atlas is out in Science Magazine as part of Human Cell Atlas: science.org/doi/10.1126/sc… w/ Eugene Drokhlyansky, Shankara Anand, Evgenij Fiskin, Ayshwarya Subramanian, François Aguet, Ayellet Segrè, Orit Rozenblatt-Rosen, Kristin Ardlie, Aviv Regev & many others 1/

The exciting reveal of Ultima Genomics last week was accompanied by the publication of four preprints. Intrigued by the potential of the technology, sina & I decided to take a look at the data. A 🧵 about our findings & a preprint we posted: biorxiv.org/content/10.110… 1/

doi.org/10.1038/s41467… or as a PDF here nature.com/articles/s4146… Our manuscript is out Gad Getz Laboratory Mark Bustoros

Out now in Nature Communications, our collab with Ghobrial Lab on finding genetic subtypes of the Smoldering Multiple Myeloma precursor condition to Multiple Myeloma that associate with clinical outcome. Great work by Mark Bustoros Shankara Anand and team!

1/13 🤔Why does multiple myeloma cause anemia and not pancytopenia? If the issue is infiltration of the bone marrow with plasma cells, wouldn't all cell lines be low? Let's have a look.

1/12 🤔Why does iron deficiency cause fatigue, even in the absence of anemia? I have often equated iron with hemoglobin and oxygen-carrying capacity. But there is so much more to it!

Hot off the press! Check out our new ms in collaboration with Dr. Catherine Wu’s lab at Dana-Farber #DFCI and colleagues from Spain, Germany and the US on creating a molecular map of #CLL from #multiomics data of >1100 patients that improves prognostics! nature.com/articles/s4158…

Our work on lung adenocarcinoma subtypes with biomarkers and clinically relevant vulnerabilities including immune checkpoint blockade response is now available online. Collaborative work with great colleagues. Thank you- Yifat Geffen Mendy Miller, PhD Shankara Anand and Gaddy Getz

What’s new in myeloma? 1/ Frontline treatment: We are recommending quadruplets as initial therapy for more patients, especially as pre transplant induction for high risk myeloma. My preferred quadruplet is Dara-VRd.

Our work is out in Cancer Cell! Read on to learn more about our use of single-cell RNA-seq to identify immune biomarkers of progression in a Phase II trial of EloLenDex in pts w/ high-risk Smoldering Myeloma (SMM).🧵👇 #mmsm authors.elsevier.com/c/1g4vW5TA51Zn… 1/

#JameelClinic PI David Sontag, Rebecca Boiarsky, Nicholas Haradhvala, JB Alberge, Romanos SP, Tarek Mouhieddine, MD, Oksana Zavidij, Ming-Chieh Shih, Danielle Firer, Mendy Miller, PhD, Habib El-Khoury, MD, Shankara Anand, François Aguet, ., & Gad Getz Laboratory present 1⃣a highly detailed & comprehensive... 3/5

Important paper iStopMM #mmsm Nature Medicine Sigrun Thorsteinsdottir Sigurdur Kristinsson Prevalence of smoldering multiple myeloma based on nationwide screening ➡️rdcu.be/c42lb Congratulations for all authors for publication , few thoughts/observations 🧵

.Shankara Anand | CLUMPS-PTM: Spatial Clustering of Post-Translational Modifications Across Cancer Types #AACR23

(1/7) As part of a suite of #CPTAC papers published across #CellPress today, we introduce our study Cell, led by Yifat Geffen, on how #PanCancer analysis of post-translational modifications reveals shared patterns of protein regulation: sciencedirect.com/science/articl…

Supporting President Donald J. Trump's #CancerMoonshot goal of accelerating #CancerResearch through improved #DataSharing, and as part of the #NationalCancerPlan, we plan to publicly release a pan-cancer proteogenomic dataset helping researchers uncover how cancers develop. cancer.gov/news-events/pr…

Very excited to share that I will be at StanfordMedRes in the Translational Investigator Pathway for residency! We are so excited to return to California and grateful for all the support and love along the way. #Match2024

We are delighted to share the #tyrosine The Kinase Library, now in nature: nature.com/articles/s4158… Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org #TheKinaseLibrary #KL #part2 🧵 1/9

Always the best part of every meeting - connecting with colleagues! Reunions with two StanfordMedRes alumni & welcoming an incoming intern with our #StanfordAmyloidCenter team! #ISA24 Shankara Anand Alfred Chung Eson Ekpo, M.D. Kevin Alexander Vaishali Sanchorawala Stanford Department of Medicine

Just a few of the StanfordMedRes interns going on a lil hike and enjoying the views before clinic orientation today 🤗 #WindyHill