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Our new perspective suggesting that 3D chromatin organization is an emergent property of chromatin-bound proteins was just published nature.com/articles/s4157…

An RNA-binding region regulates CTCF clustering and chromatin looping biorxiv.org/content/early/… RNase-sensitive CTCF self-association in vitro; RNA-binding region (RBR) mediates CTCF clustering in vivo. CTCF loops fall into at least 2 classes: RBR-independent & RBR-dependent loops

cis-Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to Complex Neurological Disorders biorxiv.org/content/early/…

Long-range single-molecule mapping of chromatin accessibility in eukaryotes biorxiv.org/cgi/content/sh… #bioRxiv

100,000 Genomes Project: WGS data for 13,037 participants, of whom 9,802 had a rare disease; genetic diagnosis in 1,040 of the 7,065 patients with detailed phenotypic data, including 99 Mendelian associations between genes and rare diseases biorxiv.org/content/early/…

If you work on any kind of predictive models in genomics, please read this paper very carefully. Extremely important to consider how you slice and design your training, hyperparam tuning and test dataset. And very imp. to compare to the per-locus average activity strong baseline.

Our paper is now online! cell.com/cell/fulltext/… We resolved the sequence of ~100K SVs with PacBio; found ~55% of VNTRs concentrated in the subtelomere and associated with male germline recombination UW Genome Sciences McDonnell Genome Institute, WashU Medicine The University of Chicago Nationwide Children's Hospital Cell HHMI

Excited to share our latest work! Q: Can we predict which enhancers regulate which genes in which cell types? With Eric Lander Jesse Engreitz and more! dlvr.it/QxYZxl

The gnomAD preprint is out! We aggregated 125,748 exomes and 15,708 genomes into a public resource of >240M high quality variants, available at gnomad.broadinstitute.org (1/5). biorxiv.org/content/10.110…

Computational Genomics Summer Institute 2019 zarlab.cs.ucla.edu/computational-…

Visualizing DNA folding and RNA in embryos at single-cell resolution nature.com/articles/s4158…

No longer only a preprint, our study on topological variation in human genomes is out Genome Biology! Waited for an updated version to announce it. Thanks to anonymous reviewers for their comments which made the manuscript better. genomebiology.biomedcentral.com/articles/10.11…

For those who listened to my talk at #ISMBECCB, a more comprehensive version of what I summarized is now published😉 genomebiology.biomedcentral.com/articles/10.11…

Our work using gene-environment interaction methods to study the genetics of drug response is now out in Cell Genomics. Cell Press cell.com/cell-genomics/…

We described the steps for estimating the heritability of drug response and identifying gene-drug interactions (the analyses we performed in cell.com/cell-genomics/…) in a detailed STAR protocol STAR Protocols. star-protocols.cell.com/protocols/4164

happy to share work from the past year that aims to determine the relative importance of various chromatin features, including TADs: biorxiv.org/content/biorxi…