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Interesting preprint about ATP gradients within cells: biorxiv.org/content/10.110…

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

🚨 New in Nature Communications: We present a spatial multi-omics platform that maps the metabolome, lipidome, and glycome from a single brain section. Combining MALDI imaging with our computational tool Sami, we reveal metabolic diversity in health and Alzheimer's disease. 🔗

Another exciting discovery from the DiNcola Lab: Dissecting redox control in lung cancer, this study demonstrates the roles of glutathione and thioredoxin in supporting Nrf2-driven progression. 📄 Redox Biology: doi.org/10.1016/j.redo…

We are also on bluesky - Visit and follow @pluchinolab.bsky.social for updates

Bacteria-derived nutrient recycling: How phagocytosed bacteria regulate macrophage metabolism dlvr.it/TKkqY5

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions go.nature.com/4568lKI

In some species across kingdoms, mitochondria have lost all sorts of functions: from specific complexes to the ability to produce ATP (and more!). We took a look at the evolutionary pathways of this reduction, from yeast and mistletoe to parasite "MROs": biorxiv.org/content/10.110…

Impairing mitochondrial fusion triggers a vicious cycle of unequal mitochondrial inheritance and failed mtDNA synthesis that rapidly depletes mtDNA: biorxiv.org/content/10.110…

🧵1/ Due to popular demand, we’re doing an X-tutorial on the new Nature Communications paper: Spatial mapping of the brain metabolome, lipidome, and glycome. Here we developed a triple-omics MALDI imaging and computational pipeline to change the game on how to study metabolism in

#Preprint alert! Pioneering work by Tanmana Mitra sheds new insights into why T cells become metabolically exhausted during persistent antigen encounter: biorxiv.org/content/10.110…

Prkra dimer senses double-stranded RNAs to dictate global translation efficiency dlvr.it/TKnKD5

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

New pre-print in the lab! Beautiful work by Francisco Garcia-Rodriguez in collab with Camila Valenzuela and Joaquín Bernal : when macrophages are provided with specific nutrients, Salmonella can bypass its requirement of the T3SS to replicate, a process that occurs within the SCV

This is interesting, de novo serine biosynthesis is upregulated as an adaptive response during mitochondrial stress cell.com/cell-reports/f…

Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at Cell! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below👇

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10.11…

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

🚨Job Alert!🚨 Nature Metabolism seeks an Associate or Senior #Editor to join our team. If being a #Metabolism Editor is for you, and you are based in, or open to moving to New York or Shanghai, check out our #job posting below and apply before June 11th! springernature.wd3.myworkdayjobs.com/SpringerNature…

Congratulations Clare Bryant ([email protected]) !!!