Let’s play a little game. Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after. Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?

lost It all

my 4yo went woke. i ask her to draw the family. doesn’t look anything like us. everyone purple and green and shit

Multistep nominative determinism: 1. GLP-1RAs are being investigated as a way to suppress alcoholism 2. GLP-1RAs are based on a chemical found in Gila monster venom 3. Gila monsters were first described by zoologist Edward Drinker Cope en.wikipedia.org/wiki/Edward_Dr…

ok this is the best one I've seen yet

The misinformation people often have latent authoritarian tendencies actually scratch that I meant explicit ones.

Happy Labor Day. To celebrate, I've written an article on why you should not support labor unions. They are anti-meritocratic cartels that achieve gains by harming the rest of society. If you are concerned with poverty, there are better ways to help. richardhanania.com/p/unions-are-n…

the ted chiang thinkpiece is lost on me because the second i saw this picture 2 years ago, i knew that not only can AI create art, it can do so far better than any human can

Right now, there's only 1 animal drug that makes over $1b per year, a biologic for atopic dermatitis. I think there could be at least 6 more, and each of them also represent $10b+ opportunities in humans. Consider this an open call for pitches. Link to piece below.

Me logging in & seeing pro-communist arguments on twitter right after my family recounted stories of people in their city caught while desperately trying to flee the communist regime that were killed and had their corpses exhibited on boats along the coast

Me and who

An expert virologist prepares lab grade virus preps (measles and VSV) & self treats her recurrent breast cancer. What happened next? Apart from an ethical minefield! The reviewers comments & rebuttals are also published and make for an interesting read... mdpi.com/2076-393X/12/9…

"Is progress in medicine too slow?" -- I try to answer why biotechnologists, economists and curious members of the general public might have different perspectives on this, going through different ways of looking at medical progress. writingruxandrabio.com/p/is-progress-… Excerpts: "After

Mario Draghi's new report on EU competitiveness doesn't mince words. "Across different metrics, a wide gap in GDP has opened up between the EU and the US, driven mainly by a more pronounced slowdown in productivity growth in Europe. Europe’s households have paid the price in

Introducing PaperQA2, the first AI agent that conducts entire scientific literature reviews on its own. PaperQA2 is also the first agent to beat PhD and Postdoc-level biology researchers on multiple literature research tasks, as measured both by accuracy on objective benchmarks

he had calculations to do

The inventor of liraglutide (one of the earlier GLP-1 drugs, like Ozempic) wrote a great history of its development. Many metascience gems on how mouse studies can both guide & mislead, the very long timelines in drug development, etc. [notes below]

I… did not see that coming. Someone fill me in on Canada pls

is this supposed to strike fear into hearts of men?

Here’s a super close-up of Saturn’s ingress, showing how it looks against the lunar limb. I shot the whole moon at this level of detail to make sure the print looks awesome at every size. If you want to support my work you can get it at the link in my bio for a few more days.