⁦Giannicola Genovese MD, PhD⁩ “EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution” ⁦MD Anderson Cancer Center⁩ nature.com/articles/s4158…

Delighted to share our new work on EMT in cancer evolution! A special thanks the fantastic mentorship of ⁦Giannicola Genovese MD, PhD⁩ and the wonderful collaborators! We found that specific genomic patterns amplify and segregate only in selected phenotypes. nature.com/articles/s4158…

Evolutionary fingerprints of epithelial-to-mesenchymal transition | ⁦nature⁩ nature.com/articles/s4158…

Out today in ⁦nature⁩ our work on the role of cell plasticity in shaping tumor evolution. Led by ⁦Luigi Perelli⁩ with critical contributions from ⁦Davide Cittaro⁩, Fei Chen and many other outstanding collaborators. 1/2 nature.com/articles/s4158…

Cancer cells leverage epithelial-to-mesenchymal transition (EMT) to promote treatment resistance and metastasis. Results from a recent MD Anderson study found that EMT is a necessary step for pancreatic tumors to become malignant. Learn more: brnw.ch/21wR9Zv #EndCancer

The role of cell plasticity in shaping tumor evolution - Giannicola Genovese (Giannicola Genovese MD, PhD) nature Luigi Perelli Davide Cittaro Ospedale San Raffaele Broad Institute MD Anderson Cancer Center oncodaily.com/blog/252364 #OncoDaily #MedTwitter #MedEd #MedOnc #MedNews #Oncology #Cancer #Health

Congrats to my friend's Yawen work! Out on cancer research☺️

This year two of our talented #MsaouelLab post-docs, Qian Jing & Kai Yu, co-mentored with Linghua Wang, MD, PhD Giannicola Genovese MD, PhD & JJ Gao each received an AACR scholar-in-training award for #kidneycancer research #AACR25 honoring their dedication to #CancerResearch #AACRScholars

Congrats 🎉🎉🎉yunhe liu Linghua Wang, MD, PhD

1/ Out today in Cancer Cell our work on spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts (CAFs)! Led by the brilliant yunhe liu with key contributions from Anirban Maitra Humam Kadara and many collaborators MD Anderson Cancer Center cell.com/cancer-cell/fu…

Thrilled to share our latest study just out in nature 😄A major milestone in our collaboration with ⁦Anirban Maitra⁩ Led by brilliant ⁦⁦⁦Guangsheng Pei⁩ ⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦Jimin Min⁩ ⁦⁦MD Anderson Cancer Center⁩ nature.com/articles/s4158…

Beautiful to see our chats turn into strategies that help patients. Excited that 2nd generation ctDNA detection via our Myriad Genetics collaboration may be a clinically actionable blood biomarker for clear cell #kidneycancer. From concept to reality in less than two years 😊

Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity Immunity Pavlos Msaouel cell.com/immunity/fullt…

1/5 People living with sickle-cell disease (SCD) face ↑ cancer risk, including #RenalMedullaryCarcinoma. Our latest Immunity study suggests a culprit is the reshaping CD8⁺ T cell chromatin by SCD 👉authors.elsevier.com/sd/article/S10… #MsaouelLab

Evolutionary insights highlight pancreatic cancer target nature.com/articles/d4247…

We are hiring! Apply if you are interested in fundamental questions of cancer biology and applying the state of the art of genetic engineering. linkedin.com/posts/luigi-pe…

🚨 New paper in Nature Genetics ! How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here! nature.com/articles/s4158…

Our study on the role of PPP2R1A mutations in cancer immunotherapy is online now! Thanks so much to the guidance and support from my wonderful mentors Linghua Wang, MD, PhD Amir Jazaeri , our fantastic collaborator Rugang Zhang Lab , and all the patients and their families!