A great overview of the clinical ADC landscape with a focus on target, payload mechanism of action, antibody, linker & conjugation method. nature.com/articles/d4157…

Very interesting and thought provoking work || Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain | Nature Neuroscience nature.com/articles/s4159…

1/ The long-awaited OS results from #KEYNOTE -564 are out NEJM! The 1st phase 3 trial to demonstrate a survival benefit for adjuvant treatment in #RCC .

nejm.org/doi/full/10.10…

Refining the impact of genetic evidence on clinical success | ⁦nature⁩ nature.com/articles/s4158…

Excited to share our new platform for hyperplexed IF spatial imaging & analysis - HIFI!

We developed this to be as #accessible & economical as possible for all interested in #spatial analysis of complex tissues

nature.com/articles/s4146…
#OpenAccess : rdcu.be/dELus

1/

How to pick a problem. Today in Cell. 1/53
cell.com/cell/fulltext/…

Our work 'Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells' is published today in Cancer Discovery (aacrjournals.org/cancerdiscover…). Using genetic tools, in 2019 Cancer Dependency Map Sanger and others reported WRN as a synthetic-lethal target in MSI cell line. 1/5

Most cancer drugs granted accelerated approval did not demonstrate benefit in overall survival or quality of life within 5 years of accelerated approval. ja.ma/3J3zZMi #AACR24

Online Now: Shifting the landscape: The role of IDH inhibitors in glioma cell fate dlvr.it/T54Vc2

1/ Thrilled to share that our paper “Impact of RCC molecular subtypes on immunotherapy & targeted therapy outcomes” is now published in Cancer Cell
Collaborative effort co-led w/ Chris Labaki & Tejas Jammihal under Eli Van Allen Sachet Ashok Shukla Toni Choueiri, MD David Braun ‘s mentorship…

Our work is finally published in Genome Medicine Thanks to Anna Golebiewska, #Alessandro and all co-authors for your guidance, contributions and support. Thanks to the #reviewers for the thoughtful comments that significantly improved the manuscript.

NOW OF

An International Replication Repair Deficiency Consortium cohort study aims to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in constitutional mismatch repair deficiency.

thelancet.com/journals/lanon…

🔬✨ Just in time for #FluorescenceFriday ! Thrilled to share our preprint on an approach to battle brain tumors! How can we understand & target the cellular networks between neurons and yet incurable brain tumors? Dive into rabies-based retrograde tracing of glioblastoma! 🧠💡…

The lab of PCGI Co-Director Dr. Ben Black leads a study in the journal Science describing vastly improved Human Artificial Chromosomes: science.org/doi/10.1126/sc…

STING licensing of type I dendritic cells potentiates antitumor immunity

science.org/doi/10.1126/sc…

Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript:
biorxiv.org/content/10.110…
See the thread below for details.

Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! biorxiv.org/content/10.110…

⚡️🔬📣Excited to share our two new Nature Medicine articles, we develop computational pathology foundation models,

1. UNI, a self-supervised computational pathology model trained on 100 million pathology images from 100k+ slides.
2. CONCH, a vision-language model for

We used platinum-related mutations to time the clonal expansion of the second tumor: if platinum mutations are clonal, the development is posterior to the treatment; if these are subclonal (A), the clonal expansion started before the treatment (B).
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Great conceptualization and use of platinum mutational signatures as barcodes to identify 1) origins of second malignancies and 2) treatment-related mutations in normal tissues