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How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by Grace Bower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/

Retinoids are a unique class of cancer drug that, by textbook definition, work by causing cancer cells to differentiate. In our new preprint, we show that there may be much more to why these drugs are effective... 1/n biorxiv.org/content/10.110…

Do preclinical models (e.g. cell lines, mice) really represent the diseases they are used to study? In our new Genome Biology paper, we explore this question using single-cell RNA-seq, with application in pediatric neuroblastoma. 1/n doi.org/10.1186/s13059…

Looking forward to this!

Tao of Night Science: it’s best to be like water. Go with the flow of the project, think conceptually, seek questions, enjoy the process, value the friendship, be generous, and don't argue over credit. open.spotify.com/episode/7FgVUv…

Phenomenal work from @MarcoGalloLab and team. New 3D genome structure found in brain tumors: cell.com/cell/fulltext/…

Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

👇 Great thread by Petri Pölönen on large-scale genomic characterization of childhood T-ALL. Spoiler: the noncoding genome plays major roles in driving this disease.

Chromatin scientists, want to reorganize genomic loci as you wish? Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/…

I am thrilled to share my preprint with #AlexisCaulier and others in Vijay Sankaran lab, showing how systematic mapping of transcription factor networks in human hematopoiesis massively enriches for heritability of blood cell phenotypes! biorxiv.org/content/10.110…. A thread below (1/n)

Beautiful work unraveling yet another fascinating genomic mechanism of oncogene activation in leukemia - not to mention adding even more layers to the complex nature of this FTO/IRX locus! Débora Sobreira

Check out the full agenda for #chromatin2024! We've got a packed schedule with incredible guest speakers and exciting talks on 3D genome architecture and nuclear topology in #cancer. Registration is FREE! See you in November 👉 bit.ly/chromatin-2024

We’re excited to share St. Jude has been recognized as one of the top 10 pediatric cancer hospitals in the US by @USNews for the 17th consecutive year. We are grateful to our dedicated team, researchers and support staff who make St. Jude exceptional. ow.ly/BSXN50THelJ

Delighted to have our preclinical study led by Richard Voit on a universal gene therapy approach for #DiamondBlackfanAnemia by regulated GATA1 expression published in Cell Stem Cell today: cell.com/cell-stem-cell…

Had a lot of fun writing this Blood Journal commentary with Ilaria Iacobucci! Check out this great study delineating a new mechanism of oncogene activation in T-ALL 🧬

My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik Bercin K Cenik did it and here it is cell.com/molecular-cell… Not

“Scientific progress doesn’t happen because every experiment or analysis works perfectly. It’s determined by how you respond when your data defies your expectations—returning the next day, reevaluating your assumptions, refining your approach, and continuing to move forward.”

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

Can we treat cancer by forcing cancer cells to differentiate? Retinoids are unique cancer drugs that, according to textbooks, make cancer cells mature and lose their malignant behavior. In our new paper, we reveal there’s more to how they really work… nature.com/articles/s4146…

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer