Iron absorption is critical for the expansion of perinatal Tregs. Beautiful work from PicoLab JCI insight Congratulations!!

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

🧬🔎Thrilled to share our latest findings on the epigenetic changes that occur post memory T cell development! Out today in Immunity! Incredible work led by Raissa Fonseca and Frank Buquicchio from team Ansu Satpathy! 🧵👇 Doherty Institute @Unimelb Stanford University cell.com/immunity/abstr…

Fantastic to see the enthusiasm of Jayendra Singh from my group ONJ Cancer Research Institute speak about metabolic regulation in Tregs at ASI VIC TAS branch Australian and New Zealand Society for Immunology meeting. Go Jay!!

How are Tregs non-inflammatory? A beautiful study in Immunity from Shimon Sakaguchi and colleagues The University of Osaka show that the Foxp3-IKZF1-IKZF3 complex displaces p300 and represses the inflammatory gene expression programs in Tregs cell.com/immunity/abstr…

Sydney Brenner's scathing indictment of modern academia in an obituary for Fred Sanger: "We no longer have a culture that allows individuals to embark on long-term - and what would be considered today extremely risk - projects."

Amazing study!!! Jeff Rathmell and team discover previously unknown immune components underlying various inborn errors of metabolism. #immunometabolism

Very proud to share that my postdoc work from @mvhlab is now published Nature Metabolism! 📢nature.com/articles/s4225… See below for details…

What did we #learn after #sequencing #5million #Tcells #scRNA and #TCRseq with @lisa_wagar Andreas Tiffeau-Mayer Suhas Sureshchandra and funding agency Wellcome Leap STLChildrensHospital -Tissue determinants of the human T cell receptor repertoire. biorxiv.org/content/10.110…

There’s never a dull day in the field of immunology!!

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday nature.com/articles/nmeth…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Understanding vertebrate immunity through comparative immunology dlvr.it/TDd5QM

Dear Treg enthusiasts from Melbourne and Victoria, we are organising the 3rd Treg mini-symposium on 11th Nov at WEHI (Walter and Eliza Hall Institute). It a free event with fantastic talks and prizes!! Please register: url.au.m.mimecastprotect.com/s/Tso7C4QOOpsg… Monash University ONJ Cancer Research Institute Doherty Institute UniMelb MDHS

Most #LaskerAward (s) recognize the thing that was discovered. In Chen’s case, we also recognize HOW he discovered it. His methods are original and breathtaking. Awards Jury Member Michael Brown honors #LaskerLaureate James Chen #Lasker2024 UT Southwestern Medical Center

New paper alert Our most recent manuscript investigating T cells in TIL-hi dMMR and pMMR colon cancer is out now iScience journal cell.com/iscience/fullt…

Beautiful work from #TeamTRM Mackay Lab on revealing retinoic acid as a key factor in establishing immune memory across tissues! This has huge potential for targeted immunotherapies in solid cancers, autoimmunity, etc. Congrats Maximilien Evrard, Andreas Obers et al.!!

An oldie (10 y!) but goodie: cellular interaction at the top! #cellcomm Video of a T cell (orange) interacting with a target cell (blue) From Chen et al Betzig (HHMI | Janelia) game changing paper, full science.org/doi/10.1126/sc… FocalPlane CellComM Lab #scicomm #microscopy

Scientists have identified #ID3 as marker for #StemLike T cells that sustain immune responses to chronic infection and cancer. Ricky Johnstone KalliesLab University of Melbourne Read more in Science #Immunology: scim.ag/4hCNlhH

Promoter evolution in HIV-1C establishes latent reservoirs highly resistant to reversal biorxiv.org/content/10.110… #biorxiv_micrbio