We are recruiting six post-doctoral fellows as part of the AZ-Crick-Imperial College Molecular Glue Discovery Partnership. Apply by 31 May. crick.ac.uk/careers-study/…

👇🏾I see the trial for #KRASG12D⛔️ 💊 by @Mirati is now open across multiple sites. Can the sponsor or the sites share details on where the study is at? So many patients with a variety of cancers including colorectal cancer & pancreas cancer. Beyond G12C.🙌🏾 clinicaltrials.gov/ct2/show/NCT05…

Lisa Hutchinson gives a great perspective on the long struggle to target RAS mutant cancers in the clinic. Not over yet!

Excited to share our new review in Clinical Cancer Research discussing current knowledge and future hopes for combing cancer immunotherapy with KRAS inhibitors aacrjournals.org/clincancerres/…

Excited to share our review about Facts and hopes of combining KRAS inhibitors and immunotherapies #openaccess in Clinical Cancer Research with ⁦Jesse Boumelha⁩ and ⁦Julian Downward⁩ at ⁦The Francis Crick Institute⁩ aacrjournals.org/clincancerres/…

Check out this opportunity to do a PhD in the best lab in the world! (Ok, I might be a bit biased...)

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a ... biorxiv.org/cgi/content/sh… #biorxiv_cancer

Another preprint from the #Downwardlab! Combining RAS G12C(ON) and SHP2 inhibition sensitizes immune cold lung tumors to PD1 inhibition. Great work by Panayiotis Anastasiou and co.!

Super excited to share the first paper from the Puig Saus lab! We have developed a new CAR-T cell therapy for melanoma and are currently working on the clinical translation, exciting times ahead! doi.org/10.1038/s41467…

Happy to share our review published in Cancer Cell. We provide an update on RAS inhibitor development, discuss the rationale for combining #KRAS inhibitors with immunotherapies, and address challenges and future directions. Julian Downward The Francis Crick Institute eur03.safelinks.protection.outlook.com/?url=https%3A%…

Local T cell neighbourhoods determine outcome in non-small cell lung cancer treatment with KRAS-G12C inhibitors. Timely and relevant work from Megan Cole and Panayiotis Anastasiou from the @JulianDownwardlab, and Claudia Lee from the Swanton Lab. doi.org/10.1101/2024.0…

Fantastic opportunity to join the #downwardlab! Great science with amazing people. I couldn’t recommend it more (a bit biased here). Please share!

We are recruiting for 3 PhD student positions, investigating different aspects of the lung cancer tumour microenvironment, within the context of an exciting EU collaboration! Great facilities & great teams! 🔬 werkenbij.amsterdamumc.org/en/vacatures/r… Apply before 6th July!

Our in vivo crispr screen paper is finally out in this issue of Cancer Research

📣 Become a versatile and efficient scientific manager with the new Master's in Health and Science Management, a joint initiative between Universitat Autònoma de Barcelona Activa't Biociències & VHIO. For more information  ➡️ linke.to/MastersDegreeH…

📣 Become a versatile and efficient scientific manager with the new Master's in Health and Science Management, a joint initiative between Universitat Autònoma de Barcelona Activa't Biociències & VHIO. For more information  ➡️ linke.to/MastersDegreeH…

#hiring #cancerresearch we have 2 open positions for technicians in the lab Vall d’Hebron Institute of Oncology (VHIO) #Barcelona, one to work on NGS assays and the other one to work with our PDX collection and in-vivo experiments. Starting date ASAP. vhio.net/2024/09/06/ref… From vhio.net📷

We have an open postdoc position in my group! The projects of the lab are focused on understanding how cancer genomes dictate immune responses, tumor evolution, and therapy resistance. Come join us in a great environment! vhio.net/2024/09/18/ref…

Research from Julian Downward Panayiotis Anastasiou and Miriam Molina Arcas at the Crick, working with Revolution Medicines, shows that combining treatments can help to eradicate lung tumours in mice. Read the full story ⤵️ crick.ac.uk/news-and-repor…

"Lung cancer is one of the hardest types of cancer to treat, so working out how to harness the immune system to better target tumours is so important." Read about the new work from Megan Cole, Julian Downward, Febe van Maldegem and more ⤵️ crick.ac.uk/news-and-repor…