Local T cell neighbourhoods determine outcome in non-small cell lung cancer treatment with KRAS-G12C inhibitors.

Timely and relevant work from Megan Cole and Panayiotis Anastasiou from the @JulianDownwardlab, and Claudia Lee from the Swanton Lab.
doi.org/10.1101/2024.0…

Exploiting the therapeutic implications of KRAS inhibition on tumor immunity - check out this review from The Crick Julian Downward & Miriam Molina Arcas in Cancer Cell #AACR24 hubs.li/Q02rwVbs0

It was a pleasure to present the #downwardlab data of how we can engage the immune system to target #KRAS G12C inhibitor resistant cells at #AACR2024 Work led by the talented Mona Tomaschko

Our paper is out! Excited to be part of such an amazing team unravelling the complexities of lung tumour/TME coevolution in #TRACERx Big thanks to all those involved in the project and who supported our work. Presented by Charles Swanton at #AACR24 Check out our Tweetorial below.

So so happy to share our latest lab paper in Nature Communications dissecting the influence of oncogenic pathways on immune cell shaping in #HCC ! A 🧵 doi.org/10.1038/s41467… 1/n

Happy to share our review published in Cancer Cell. We provide an update on RAS inhibitor development, discuss the rationale for combining #KRAS inhibitors with immunotherapies, and address challenges and future directions. Julian Downward The Crick eur03.safelinks.protection.outlook.com/?url=https%3A%…

Interested in studying cancer #DrugResistance using cutting-edge gene editing and single-cell RNA sequencing approaches Wellcome Sanger Institute?
One week left to apply!

PDF ->
sanger.wd3.myworkdayjobs.com/en-US/Wellcome…
ARA ->
sanger.wd3.myworkdayjobs.com/en-US/Wellcome…
ARA ->
sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

Super excited to share the first paper from the Puig Saus lab! We have developed a new CAR-T cell therapy for melanoma and are currently working on the clinical translation, exciting times ahead! doi.org/10.1038/s41467…

Delighted to share our latest work, out in Nature Immunology, tackling the seemingly inordinate complexity of #cDC2s . Caetano Reis e Sousa The Crick, we found that distinct ontogenetic lineages dictate cDC2 heterogeneity, rather than cell states imposed by the tissue microenvironment 🧵(1/x)

Cancer immune checkpoint blockade tends to be ineffective in tumours with an immune excluded microenvironment. In a new preprint from our lab we show how to make these cold lung tumours responsive to immunotherapy by targeting KRAS and SHP2.
biorxiv.org/content/10.110…

Hope you can join Max and I at the keystone meeting we have organized on Myeloid Targeting Strategies for Cancer Treatment, this May in Killarney! keysym.us/KSMyeloidTarge… #KSMyeloidTargets24

Our last preprint is now online #Downwardlab ⁦Julian Downward⁩. Combining RAS G12C(ON) and SHP2 inhibitors we sensitise anti-PD1 refractory tumours to immune checkpoint blockade. Led by the talented ⁦Panayiotis Anastasiou⁩ biorxiv.org/content/10.110…

After a 12-day strike we have reached a tentative agreement with Icahn School of Medicine at Mount Sinai! This is a massive achievement and would not have been possible without years of efforts by hundreds of postdocs and our incredible allies who stood with us ✊🏽 #1u

Our courageous postdoc research scientists deserve a strong first contract that expands housing access and meets their childcare needs. There is no research without the researchers.

Proud to stand with Sinai Postdoctoral Organizing Committee-UAW 💪🏽

Very excited to share two papers published today in Cell describing stem cell plasticity in CRC. (1/22)
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…

🚨 I’m super excited to share my PhD work at The Crick in the Tybulewicz Lab, published in Nature Communications!

➡️nature.com/articles/s4146…

#Tcells are some of the fastest-moving cells. What makes them so quick?

- It turns out that salt🧂& water 🥤 are the key!
A 🧵on some highlights:

📢 Tomorrow we are walking out of the lab Icahn School of Medicine at Mount Sinai Mount Sinai Health System for a better academia that supports everyone, not just the privileged. Join us on the picket line. #StrikeReady #1dayToGo ✊

I am excited to announce the publication of our manuscript out today, with Philippe Gui, Charles Swanton, Swanton Lab, Bivona Lab, @Downwardlab, and The Harris Lab! 🧵 1/15
nature.com/articles/s4158…

Are any UK clinical trainees interested in RAS translational research? Don't hesitate to get in touch re this PhD now advertised. Fantastic opportunity working with
Angeliki Malliri and an amazing team
Manchester Cancer Research Centre
KRASKickers
Division of Cancer Sciences
The University of Manchester

Murphy lab is hiring! PREDICT-Meso Cancer Research UK in Scotland Asthma + Lung UK CRUK Scotland Inst
We are seeking a brilliant postdoctoral scientist to investigate how inflammation and genetics combine to drive mesothelioma. Please retweet & see.. my.corehr.com/pls/uogrecruit…