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Thrilled to announce our next event Aging Initiative at Harvard with Norn Group: the Muscle Aging Science & Translation symposium Harvard Medical School, featuring David J Glass MD Regeneron, Anne-Ulrike Trendelenburg Novartis, Andrew Adams Eli Lilly and Company, Jeff Nippard, Brad Schoenfeld, PhD, Dr. Roger A. Fielding, PhD

🦴Check out Skeletal Muscle's March Featured Article! David J Glass MD doi.org/10.1186/s13395…

Very impressed with these students. Very proud of Regeneron for allowing them to be recognized and encouraged in this way.

The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis sciencedirect.com/science/articl…

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers …eletalmusclejournal.biomedcentral.com/articles/10.11…

It was really humbling to organize the Muscle Aging Symposium with my team Aging Initiative at Harvard alongside Norn Group last week. Truly so much heavy lifting ahead of us in therapeutic development for the muscle, metabolism, and frailty spaces, but some exciting tailwinds!!

We heard from industry leaders David J Glass MD Regeneron, Anne-Ulrike Trendelenburg Novartis, and Ken Attie alongside Andrew Adams Eli Lilly and Company. A masterclass on topics like bimagrumab, target discovery, genetic medicines, and much more from the absolute best in the business.

Photorealism.

Congratulations David J. Glass of Regeneron, newly inducted #NASmember! #NAS162 #medicine

Scientists should reject frameworks in which they may be proved "right" or "wrong" - either claim is problematic. Scientists should simply ask questions to frame their experiments; the resultant data will provide the answer. Reproducible data is always the correct answer.

If you frame an experiment with a hypothesis or expectation, and then set out to test that claim, you're always at risk of both confirmation bias and, even worse, establishing a system only capable of finding what you're looking for. Framing with a question forces a wide net.

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging cell.com/cell-metabolis…

So-called magic pill has no effect

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial nature.com/articles/s4146…

Federal Reserve Chair Jerome Powell gave the commencement address at Princeton yesterday. Among his remarks: “At the end of the day, your integrity is all you have. Guard it carefully.”

Is taurine an aging biomarker? Apparently not. Do taurine levels correlate with any sort of health status? Apparently not. Were prior high-profile claims as to the benefits of taurine reproducible? Apparently they were not. science.org/doi/10.1126/sc…

Half my career has been showing a prior claim that X causes Y is not reproducible. Once or twice we found that X caused the opposite of Y. Often we found that Z rather than X caused Y. Sometimes we found that X does cause Y, but also causes some other very very bad things.

No one reads your paper more closely than your biggest competitor. Therefore you should work hard to make sure it's bullet-proof, no?