After a long Twitter hiatus because... life... I'm back to bring you this endometrial lesion in a 42 yo woman with abnormal uterine bleeding. Hysteroscopy showed an endometrial polyp in the lower uterine segment #GynePath #GynPath #PathTwitter

Rectal Polyp. #PathTwitter

🖊️Ovary, adult #gynpath #GIpath #pathtwitter #pathresidents

Hepatic metastasis of gastric malignant gastric glomus tumor. The primary harbored a NOTCH2-MIR143 fusion; actin and basement membrane labeling around each cell using collagen IV stains are confirmatory. Without history, the top choice would be treated GIST. #umiamipath

🔬 La Société Française de Pathologie et les Annales de Pathologie s'associent pour l'édition 2024 du concours photo 📸 ⏳ Vous avez jusqu'au 1e octobre pour y participer! 👉 Toutes les infos sont ici : docs.google.com/forms/d/1i7Vk7… #pathart #pathology #francophonepath Société Française de Pathologie

___-like staining for carbonic anhydrase IX is diagnostic for clear cell papillary renal cell tumor A) Cup B) Box #GUPath #PathTwitter #Pathology #Pathologists 🙏🖼️ from Nick Baniak

#PathTip #GUpath #LPpath: when screening prostate biopsies at low power &👁️ small glands traversing from one side of the core to the other ("glands crossing the street"): definitely🛑stop &📷 go down on high power!

Bread and Butter: It's easy to overlook T4a colorectal carcinoma when mesothelium (indicated) extends up along adipose tissue lobules. In this case, the cancer cells link to the mesothelial cells via inflammation. #umiamipath

A stunning example of a giant condyloma; this one was probably human papilloma virus (HPV) 6 driven - in situ hybridization using an HPV6/11 cocktail was reactive. #umiamipath

Pap smear. atrophy #cytopath #papsmear #PathTwitter

#gynpath frozen, ovarian tumor, elderly female. I only got to see the permanents, no struggle there. Attending showed me the frozen, thought it was pretty cool & educational! Care to take a guess? I'll post H&E from surgical specimen later. #PathTwitter

55-year-old woman with uterine prolapse. What is your interpretation? A) NILM B) ASC-H C) Endometrial adenocarcinoma D) Non-keratinizing SCC #Cytopathology #CytoPath #PathTwitter #Pathology

Adult female, reproductive age, omentum. #BSTpath #Gynpath #GIpath #Pathtwitter #Pathresidents

#1 of 2: Glandular cells on a pap. Interpretation? A) Metaplastic B) Neoplastic #CytoPath #GynPath #PathTwitter #Pathology

Pitfall alert ‼️ SOX10 positivity in basaloid-type SCC. Don’t confuse it for a salivary carcinoma in head & neck (this case was from oral tongue and p16-). Avoid using “basaloid” loosely its a specific subtype with dysplasia and characteristic cribriform collagen (PMID:3770734)

An Institutional Experience of Core Needle Biopsy with Cooperative Implementation by Pathologists and Head and Neck Oncologists in Salivary Gland Carcinoma Kobayashi K, et al. rdcu.be/d8TwP #HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #PathologyTweet

Pitfalls of p63: Case 2 This is an imaging-detected mass consisting of small irregular glands in a densely fibrous background. IHC showed marked attenuation and loss of p63 in a majority of glands, raising concern for invasive carcinoma. What is your diagnosis?

Ovarian involvement by Uterine Leiomyosarcoma is uncommon. The presence of angiolymphatic invasion and the absence of ovarian surface involvement favor metastasis over direct spread.

Molecular Features: 🧬NUT (Nuclear Protein in Testis) is typically found only in post-meiotic spermatogenic cells & ciliary ganglion. 📔BRD4-NUTM1 fusion gene (discovered in 2003) is the most common. ✒️Over 50% nuclear positivity on IHC = diagnostic. ✒️Other NUT

Probably the four most frequent scenarios when we face thyroid cytology - The Bethesda System: I - Non diagnostic II - Benign: Follicular nodular disease IV - Follicular neoplasm VI - Papillary thyroid carcinoma #EndoPath #CytoPath #FNAFriday