Very happy to announce that today two papers on #PhIPSeq in (1) the general population (🧵 by Sergio Andreu-Sánchez) and (2) in patients with inflammatory bowel diseases (#IBD), got published today in Immunity authors.elsevier.com/c/1h2md3qNrUu3… doi.org/10.1016/j.immu… 🧵 on IBD findings:

Chancellor, Simmons, De Libero University of Basel, Lepore et al. show that promiscuous recognition of MR1 by canonical MAIT TCRs endowed w/ dual reactivity to both microbial and self-antigens enables MAIT cell responses in the absence of microbial infection. bit.ly/3JEyJQe

Exciting news from our lab! 🧵👇 Our latest study on tissue T cell heterogeneity, led by Maximilien Evrard is now published in Immunity Doherty Institute authors.elsevier.com/c/1hL2j3qNrUu3…

Our work on fine-scale identity-by-descent clusters in the UCLA ATLAS Biobank was published online today! I'm immensely proud of this work and its implications for the health of diverse populations in my home, Los Angeles 🌴 nature.com/articles/s4159…

Always been a bit surprised by the low % of colocalization of eQTLs and GWAS hits. One rationale is that we weren’t looking at the right cell type we need single cell gene expression. New paper presents evidence for another reason: context specific eQTLs biorxiv.org/content/10.110…

🥳🥳🥳Couldn't be happier to see our study on mucosal-associated invariant T (MAIT) cells in HCC published today in Cell. Article: authors.elsevier.com/c/1hbwdL7PXmdKm Brief summary of this exciting collaborative work between @TimGreten lab and Claassen Lab below (1/11):

Thrilled to share our latest work out now in Science Magazine demonstrating a heterozygote advantage at HLA-II in protecting against lung cancer risk in smokers! Check out Diego Chowell’s tweetorial below👇

Excited to share our HLA-pQTL study revealing widespread HLA trans effects on protein expression in UK Biobank- now out at Nature Communications with Xinli Hu, Josh Chiou, Soumya Raychaudhuri সৌম্য রায়চৌধুরী, Saori Sakaue, Joyce Kang, PhD, and many more Pfizer Inc.! nature.com/articles/s4146…

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk Haotian Du Jingjia Liu SgourakisLab Stanford Biosciences Penn Allergy and Immunology CHOP Research

Thrilled to share our latest work on broadening T cell help for developing better flu vaccines Science Magazine Sarah Ross Grateful for Mark Davis’s invaluable mentorship Stanford Medicine Stanford Immunology buff.ly/4flV5TK 1/n

Online now: Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis dlvr.it/TH1J1k

Excited to share our latest work on the thymus, out Immunity! We define thymic mimetic cells in humans and show they are an evolutionarily ancient component of adaptive immunity. Terrific collab w Cardiac Surgery Boston Children's and Dr. Len Zon lab. cell.com/immunity/abstr…

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

There is an increased risk of autoimmune diseases after Covid, and 2 constituents of the virome (anellovirus and HHV-6) may help to explain this link nature.com/articles/s4158… Nature Genetics a study of 5 different autoimmune diseases in over 6,300 Japanese individuals with Covid or

Who would benefit from checkpoint inhibitor immunotherapy for cancer? A machine learning model based on routine lab tests and basic clinical data outperformed FDA approved biomarkers (such as PD-L1) nature.com/articles/s4159… Nature Medicine from nearly 10,000 patients

Poli et al. present the 2024 update of the International Union of Immunological Societies classification of human #InbornErrorsOfImmunity including 67 novel monogenic defects and 2 new phenocopies. hubs.la/Q03hwJPX0 See also Bousfiha et al.’s accompanying guide for physicians hubs.la/Q03hwM_T0

Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlocking high-throughput functional TCR screening from single-cell data. 🧵Koch Institute at MIT Michael Birnbaum MIT ChemE Dept Massachusetts Institute of Technology (MIT) biorxiv.org/content/10.110…

🤯Three (!!!) new papers today in Science Magazine on the application of generative AI for the de novo design of peptide/HLA binding molecules! Completely unique 3D structure and binding mode compared with natural TCRs and TCR mimics! Links to papers 👇