Small Molecules of the Month, Feb. 2020 - drug-hunter.com/2020/03/01/smo… Highlights from SMDD campaigns published online Jan-Feb. Grab a coffee and use this post as a starting point in getting caught up on the literature this year! PDF and links to articles in the post #chemtwitter

Why outbreaks like coronavirus spread exponentially, and how to “flatten the curve” wapo.st/39MCAqB

Calling all medicinal chemists! We released ~60 structures of fragments bound to the Mpro #SARS_COV_2. diamond.ac.uk/covid-19/for-s… We are crowdsourcing ideas for what to synthesise and test next covid.postera.ai/covid you design it and we'll test the best designs. please RT!

New video: Simulating an epidemic. What happens when people avoid each other for the most part but still go to a common central location like a store? What if you can track and isolate cases, but 20% slip through the cracks? 50%? And much more. youtu.be/gxAaO2rsdIs

A further step in the development of a RIOK2 chemical probe. Congratulations to the UNC-Chapel Hill team! Structural Genomics Consortium (SGC) RSC Medicinal Chemistry #darkkinase pubs.rsc.org/en/content/art…

Check out our synthetic strategy to diversify purine libraries for drug discovery. Online on ChemRxiv doi.org/10.26434/chemr… BOOMchemistry.com Juan Diaz Mochon

Synthesis and screening of 6-alkoxy purine analogs as cell type-selective apoptotic inducers in Jurkat cells dlvr.it/S1r9XG

Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi mdpi.com/1173114 MDPI ISGlobal Facultad de Farmacia GENYO Juan Diaz Mochon BOOMchemistry.com

10 years of research culminates with this work. Our most important contribution to the cancer field. Joint effort from Edinburgh Cancer Research, @MRC_CRH and CIB Margarita Salas (CSIC)!! cancerres.aacrjournals.org/content/early/…

Nuvectis Pharma has licensed rights to develop and commercialize a novel, SRC/YES1 inhibitor discovered at the CRUK Edinburgh Centre Edinburgh Cancer Research of the University of Edinburgh’s Institute of Genetics and Cancer Institute of Genetics and Cancer. Read more on Yahoo! Finance 👇: finance.yahoo.com/news/nuvectis-…

Interested in the chemistry behind approved kinase inhibitors? Check out the comprehensive perspective in Journal of Medicinal Chemistry by BOOMchemistry.com here: fal.cn/3iYbC

For those interested in #bioorthogonal catalysis, check out this new application just published in Angewandte Chemie in collaboration with Becker Lab CRTDresden 😷 onlinelibrary.wiley.com/doi/10.1002/an…

Interested to learn more on how molecular organisation, handedness and configuration can aid in synthetic biomaterial design? Check out our recent review here ➡️ pubs.rsc.org/en/content/art… Chem Soc Rev @rcontmont, Amanda Ellis, Palli Thordarson and Jonathan Steed

See our last work here: pubs.acs.org/doi/10.1021/ac… After years of research, we show "Pd-triggered local chemotherapy" works in vivo and can solve inherent DMPK issues of a chemotherapy drug such as 5FU ACS Publications Bio & Med Chem Content Edinburgh Cancer Research Institute of Genetics and Cancer @CRUK_BI

Congrats to Shiao for her work JACS Au! BOOMchemistry.com Excited with the potential of this targeted strategy. pubs.acs.org/doi/10.1021/ja…

💊📢 New paper on #AI for #drugdiscovery in Nature Communications We discovered three senolytics - compounds that kill 'zombie cells' in therapies vs cancer and others #aging doi.org/10.1038/s41467… The most fun collab led by Vanessa Smer-Barreto with Juan Carlos Acosta lab #compchem #synbio

🌞Delighted to see our work with Vanessa Smer-Barreto Juan Carlos Acosta BOOMchemistry.com and the Carragher lab on featured in the press today! thetimes.co.uk/article/ai-fin… news.sky.com/story/ai-helps…

Interested in using degron tagging to study the function of your favourite protein in genetically engineered mouse models? Check out our review covering recent work in this area: doi.org/10.1242/dmm.05…