All rejected papers share one common flaw: a weak discussion section. I know because I used to write them too. If you're stuck on the discussion section, wondering how to tie it all together, this is for you:

Alzheimer's disease result from complex interactions of risk factors that cause pleiotropic changes in protein networks. In the largest CSF proteomic studies, we identified more than 2000 proteins dysregulated in #Alzheimer. cell.com/neuron/fulltex… WashU Medicine Knight ADRC WashU Medicine Neurology

During post-talk questioning session at the #ADPD #2025 I presented the recent work from Cruchaga Lab at WashU Medicine in which we mapped #CSF and #Plasma proteome across #Neurodegeneration

Cohort study of the week -The study “𝗠𝘂𝗹𝘁𝗶-𝗰𝗼𝗵𝗼𝗿𝘁 𝗰𝗲𝗿𝗲𝗯𝗿𝗼𝘀𝗽𝗶𝗻𝗮𝗹 𝗳𝗹𝘂𝗶𝗱 𝗽𝗿𝗼𝘁𝗲𝗼𝗺𝗶𝗰𝘀 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝘀 𝗿𝗼𝗯𝘂𝘀𝘁 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝘀𝗶𝗴𝗻𝗮𝘁𝘂𝗿𝗲𝘀 𝗮𝗰𝗿𝗼𝘀𝘀 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝗰𝗼𝗻𝘁𝗶𝗻𝘂𝘂𝗺”, led by

Farhad Iman and colleagues present the Global Neurodegeneration Proteomics Consortium dataset – 250 million unique protein measurements from 35,000 samples. Samples were provided by 23 research communities. Authors identify proteins associated with AD, PD and ALS.

Interested in knowing more about the overlap & distinctions in the CSF/plasma proteomic landscape of #AD, #PD, #FTD, & #DLB? Feel free to checkout my #Poster #240 on Sunday 27th July (8am - 4pm) and #Talk (4-29-FRS-C) on Wednesday 30th July in Hall G at 5pm. #CruchagaLab #AAIC25