🤯 in Cell An alternate receptor for adeno-associated viruses cell.com/cell/fulltext/… carboxypeptidase D [CPD] is an alternate AAV receptor- totally explains why AAV8 vectors are SO efficient at pancreatic exocrine cell transduction for CRISPR engineering.

A special Journal of Clinical Investigation series on #PancreaticCancer led by Ben Stanger jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… Articles by Laura DeLong Wood Muir Lab Maddipati Lab

Top!! Congratulations to Ben Stanger for the lead

We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! sidolilab.org/single-cell

Thank you Yilong Zou Lab and Charles David for this thoughtful commentary on our recent study connecting PCSK9 status with PDAC metastatic tropism

Excited to share our new preprint on bioRxiv from our great team @EMBL! biorxiv.org/content/10.110… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus

bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.

The source of dietary fat influences anti-tumour immunity in obese mice go.nature.com/4o2w4CJ

Again I would like to thank Fondazione Pezcoller for inviting me to their 36th Pezcoller Symposium in beautiful Trento. They were warm, pampering and wonderful hosts and science was top notch and delightful. I had fabulous time!

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts | Nature Metabolism nature.com/articles/s4225…

Excited to share our latest story Nature Communications. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors: nature.com/articles/s4146…

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction go.nature.com/3H6yuzC

🚨❗ Results of the FIRST EVER trial comparing ultra-processed food (UPF) and minimally-processed food (MPF) diets following healthy dietary guidelines on health (and the longest trial of UPF to date) published today in Nature Medicine What did we find? A Thread… 🧵 1/

#ImmunometabolismPower! Bombardieri, Mauro, Certo &co show Nature Metabolism that #lactate drives the formation of ectopic lymphoid structures which sustain #autoimmunity/ rheumatic disease activating T/B cells & that targeting lactate uptake is protective! nature.com/articles/s4225…

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by Fikadu G. Tafesse & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

Depending on your data type, use the right plot to tell the story. A nice interactive app to determine what plots you need data-to-viz.com

The Role of Micronutrients in ATP (energy) Production Micronutrients, although required in minute quantities, are indispensable catalysts in the metabolic pathways that convert food into energy. These pathways, include glycolysis, the Krebs cycle, and the electron transport

#WeekendRead! #WeAreWhatWeEat, #MicrobiotaPower! Takeuchi, Ohno &co show Cell Metabolism that acetylated cellulose reduces body weight gain in lean & obese mice by favoring microbiota utilization of simple sugars, forcing hepatic fatty acid utilization! dlvr.it/TMKzHY

No driver mutations could be identified in 181 tumors. The authors do not know why. Perhaps, it's an algorithmic failure. Perhaps, it reflects non genetic contributions to carcinogenesis. What do you think ?