#LongCovid Has Forced a Reckoning for One of Medicine’s Most Neglected Diseases “At best, most medical professionals know nothing”—“#MECFS ‘just isn’t taught’. Most curricula don’t include it; most textbooks don’t mention it.” Ed Yong, The Atlantic 2022 archive.ph/gsqGA

Jacob Biasetti thetranscendedman > causation is always convoluted in complex systems One great explainer on why & how this affects the way we seek to understand biological systems can be found in chapter 12 of The Entangled Brain, a fully open-access neuroscience book. Luiz Pessoa 2022 doi.org/10.7551/mitpre…

I am running out of time. I am out of energy and resources. I have never been less capable of communicating the severity of my situation. I have never been less capable of attaining the help I need. I have never needed help more. I have never been worse. I have three weeks.

> RBC capillary velocity is compromised in #MECFS > Research priorities: drugs that can improve RBC deformability How about the classic nootropic #piracetam? “improves blood flow by increasing erythrocyte deformability” Behavioural Brain Research 2025 doi.org/10.1016/j.bbr.…

Chris Alvino > when my brain fog is bad and I take a high dose of creatine, I feel something happening in my head ~30 minutes later—I just think it's weird That sense of relief is always a weird experience. With #creatine, it also seems quite weird *physiologically*. I’ll try to explain. 🧵

Chris Alvino >> Why would #Creatine help with #BrainFog? > tl;dr: Don’t know about y’all, but I find this really weird If there’s any takeaway here, for me it would be realizing that even relatively tiny interventions *can* make a big difference—the brain’s not broken, it just needs help. 🙏

Some people who don’t “think for themselves” and don’t “do their own research” really should

Persisting Impact of Psychosomatic & Psychiatric Misdiagnoses • adverse outcomes in multiple domains of wellbeing • vulnerability to confirmation bias • damage to sense of self & worth • fear of future disbelief Rheumatology 2025 doi.org/10.1093/rheuma… #MedicalGaslighting

Zdenek Vrozina > More than 2 years after infection, people with #LongCovid still show signs of a leaky BBB Great explainer thread—I especially appreciated the acknowledgement that we knew to expect this. One implication: medications such as #antihistamines may have surprising central effects.

Look E. Lou J.H.Nosey Zdenek Vrozina > we may not—or should not—always presume BBB integrity For #antihistamines to stay out of the brain, they need to be *actively* kept out by a BBB transporter called P-Glycoprotein. Many neurodegenerative insults, eg. lipopolysaccharide-induced #neuroinflammation, affect P-gp.