glad to share our article on the genetics of cryptogenic stroke in Annals of Neurology doi.org/10.1002/ana.26… reflecting my work CGM at MGH Broad Institute Main message: genetics don't respect our diagnostic boundaries

Many thanks to all the co-authors Chris Anderson Jonathan Rosand MD MSc Ernst Mayerhofer James Pirruccello @rainermpg ISD Research and everybody else not on twitter and acknowledgements to DFG public | @[email protected] for funding my stay in Boston

I am excited to share an article published today in Frontiers in Neurology, on which I have worked during the last three years. Thanks to @cdandersonmd and all other contributors! frontiersin.org/articles/10.33…

I am happy to share our recent work on statins and intracerebral hemorrhage that illustrates how genetic variation of drug response can be used to assess drug effects. Many thanks to @mgeorgakis1 @cdandersonmd @rainermpg @jrosand_md Stephen Burgess and others medrxiv.org/content/10.110…

ICYMI: "Genetically predicted on-statin LDL response is associated with higher intracerebral hemorrhage risk" led by Ernst Mayerhofer and @mgeorgakis1 at medRxiv: medrxiv.org/content/10.110…. Not the first example of this approach I've seen, but a really interesting one. Thread follows!

While the benefits of statins for preventing vascular disease are well-established, Mayerhofer et al. show that genetic factors influencing the response to statins are also associated with risk for intracerebral haemorrhage. bit.ly/3PBAbV1

Have a look at our Mendelian randomization study exploring the effects of genetically predicted on-statin LDL response on risk of ICH that just came out in Brain Ernst Mayerhofer Chris Anderson @rainermpg Stephen Burgess CGM at MGH Broad Institute McCance Center for Brain Health at MGH academic.oup.com/brain/advance-…

Glad to share our work highlighting the importance of treating uncontrolled BP in ICH survivors irrespective of hemorrhage location published in the official journal of European Stroke Org journals.sagepub.com/doi/10.1177/23…

Just out! 📢 📢 📢 The largest study on stroke genetics 🧬 with more than 2M individuals (incl. >200,000 cases) just published in nature! Have a look here 👉 nature.com/articles/s4158… 🧵1/7

Happy to share our most recent work on PRS in ICH demonstrating how genetics can improve prediction in a clinical setting. Thanks to Chris Anderson @mgeorgakis1 Jonathan Rosand MD MSc @rainermpg et al for amazing mentorship!

Can polygenic scores be used in clinically relevant scenarios? Have a look at our Stroke AHA/ASA paper by Ernst Mayerhofer Chris Anderson, where we show that adding a PRS for ICH to HAS-BLED in patients under anticoagulation improves risk stratification for ICH ahajournals.org/eprint/5D6QGU6…

Delighted to contribute to this paper led by Ernst Mayerhofer showing that CHIP is enriched among young pts presenting with strokes of unknown etiology, including how CHIP testing changed the management for a subset of patients ahajournals.org/doi/10.1161/ST… Stroke AHA/ASA

Enhanced risk stratification for anticoagulation-related intracerebral hemorrhage 💊🩸 is achieved with the use of a genetic risk score 🧬. Recently published in Stroke AHA/ASA Get to know more at ⬇️ ahajournals.org/doi/10.1161/ST… Ernst Mayerhofer @livia_parodi Chris Anderson