Loving that Disney keeps dropping these kind of papers: arxiv.org/pdf/2512.16705

Another awesome robot by Disney. Very bullish on their future theme parks.

A weekly jab in the belly is generating more revenue than the entire AI industry. Ozempic + Mounjaro: $71B in 2025. OpenAI + Anthropic: $29B. And they've barely started. ~2% of the 800 million eligible patients can currently access them. h/t Samuel Hume

In search of the lost tribe of clinical,y meaningfully sarcopenia after #weightloss with GLP-1 medicines A new review nature.com/articles/s4136… #obesity International J Obesity

New Therapeutics Review—Targeting MEK in cancer and beyond: mechanistic insights and therapeutic opportunities 🔗 spkl.io/6011A4C8b

"There is also compelling preliminary evidence suggesting that the use of these drugs [GLP-1] could exacerbate and lead to new diagnoses of restrictive eating disorders, including anorexia nervosa." NEJM today nejm.org/doi/full/10.10…

Cost-Effectiveness of Tirzepatide for the Management of Heart Failure With Preserved Ejection Fraction and Obesity Tirzepatide seems to be a cost-effective treatment option for patients with HFpEF and obesity in the United States. However, the modest 51% probability of

Fernandez Garcia, M., Retallick-Townsley, K., Pruitt, A. et al. Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo. Nat Neurosci (2026). doi.org/10.1038/s41593…

Spouses of Alzheimer's patients are 6 times more likely to develop Alzheimer's themselves. They share daily saliva exchange for decades. Their oral bacteria converges to the same strains. In 2019 Cortexyme published a paper in Science Advances showing Porphyromonas gingivalis,

How worried should we be about powerful new AI models like Anthropic's “Mythos,” which the company has deemed too dangerous for public release? I asked Council on Foreign Relations senior fellow Sebastian Mallaby, who has just written a new book called “The Infinity Machine: Demis Hassabis, DeepMind, and

A growing body of research suggests that GLP-1 drugs do more than control appetite and blood sugar. They could also fight inflammation spklr.io/6011EKg5R

This NYT Magazine article on longevity science, reversing aging with cellular reprogramming, by Susan Dominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing cancer. gift link

Princeton researchers have combined brain cells and advanced electronics into a 3D device that can be programmed to recognize patterns using computational techniques. bit.ly/3ORqvu2

Expanded benefits reported today for GLP-1 therapy JAMA Dermatology Extragenital lichen sclerosus jamanetwork.com/journals/jamad… Potential for psoriasis, a review of evidence jamanetwork.com/journals/jamad…

New nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple

What is the most established intervention linked to lower biological (epigenetic) age? Exercise A new systematic review The Lancet Healthy Longevity of 44 studies, >145,000 participants thelancet.com/journals/lanhl…

An AI program performed better than human doctors on reasoning tasks such as making emergency room decisions and diagnosing complex cases, according to a new study published Thursday in Science Magazine sfchronicle.com/health/article… science.org/content/articl…

First randomized trial to show Ozempic reduces alcohol consumption in people seeking treatment for alcohol use disorder. Placebo-controlled, double-blind. Participants with BMI >30 kg/m2. thelancet.com/journals/lance… The Lancet

“If AI can model cells, science can deliver cures” Great article from TIME about virtual cell 🔥 Every breakthrough AI model needed a data moat. ESM had evolution (ie, billions of years of implicit perturbation experiments encoded in sequence diversity). AlphaFold had the

Exciting new insights on CpG islands (CGIs) regulation by transcription factors (TFs)!  CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. biorxiv.org/content/10.648… 1/9