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Challenging dogma: When mutations don't change the amino acid (synonymous) but alter the fitness of the protein, and can be as harmful as non-synonymous mutations nature.com/articles/s4158… nature.com/articles/d4158… nature Nature News & Views

Common germline variants can predict the risk of cancer development📈, but can they affect somatic alterations🧬? Yes! they have universal effects on mutations and SCNAs across cancer types. ➡️See doi.org/10.1158/0008-5… published in Cancer Research today!

Academic writing is a superpower. It's a key to publishing, getting a new job or tenure, and becoming known in the field These 10 AI-powered websites will help you with EVERY part of your manuscript and will save you 100+ hours: #openscience #AcademicTwitter #phdvoice #phdchat

Here's a basic Zotero workflow that you can master in 20min to supercharge your research (even if you've never used Zotero):

If you choose to transfer a manuscript between Nature-family journals, you can consult a web page that lists the acceptance rates for 124 journals published by the Springer Nature Group. I haven’t seen this data circulated before, so I copied it to share here:

Synonymous mutations have massive effects on protein activity. Never knew that. Take a protein & make a fast + slow-translated version. For one enzyme, fast translation caused 20% drop in activity. Simulation + experiments show "entangled states." Weird. nature.com/articles/s4155…

Wow, I wish I would have had this as a graduate student! This is extremely useful 😊

Scaling scRNA-seq data by log(p/s+1) outperforms other approaches, including recent methods with thousands of citations. [Ahlmann-Eltze & Huber, 2023 Nat Methods, nature.com/articles/s4159…]

We are excited to release Seurat v5- with new methods for multimodal, spatially resolved, and massively scalable single-cell analysis. satijalab.org/seurat

A fascinating report nature today on the bidirectional interaction of brain/mind and cancer nature.com/articles/d4158… nature.com/articles/s4158…

A #single-cell atlas of the human #lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for generating organ-scale cell atlases. Lisa Sikkema Malte Luecken Fabian Theis nature.com/articles/s4159…

The magic and deleterious effects of resident macrophage cells in health and disease, a new tour de force review nature nature.com/articles/s4158…

～今年もやります、遺伝統計学・夏の学校～ We have "online" summer school of Statistical Genetics🧬🖥️💊. Aug 25th-27th, 2023📅by Osaka Univ, Univ Tokyo, RIKEN IMS. Any students with interests in stat genet are welcome !! #Genetics #gwas #SummerSchool #omics sg.med.osaka-u.ac.jp/school_2023.ht…

First GWAS hit for Long COVID! Indicating only partial overlap with COVID-19 severity Great leadership by Hanna M Ollila Hugo Zeberg Vilma Lammi Tomoko Nakanishi Samuel Jones Supported by the COVID-19 Host Genetics Initiative network

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Good afternoon from DC! Looking forward to listening to some exciting science at the #ASHG23 over the next five days. Here are some highlights—scheduled talks that sparked my interest—grouped under themes (time well spent during my train trip from NY to DC). Whole genomes As

RGC million exomes browser is here (~20% non-Europeans). Don't miss this amazing resource to query variants and genes of your interest. It'll greatly complement the gnomAD v4 browser. Bookmark it today and spread the word.

I'm absolutely thrilled to share that our work on human centromere variation and evolution has been published in nature! We completely sequenced all centromeres from a second human genome & compared them to those from the first complete human genome, uncovering new sequences,

Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in nature, we report that lung-specialized alveolar fibroblasts orchestrate lung homeostasis, inflammation, and fibrosis. 🧵👇(1/n) nature.com/articles/s4158…