Excited to see our paper 'Decoding Chromatin States by Proteomic Profiling of Nucleosome Readers' out in nature!
rdcu.be/dAv5S
Explore our data on how epigenetic modifications modulate protein binding to chromatin with MARCS marcs.helmholtz-munich.de
Details below 👇

🔔We are excited to announce ICBS2024 conference in Toronto, October 27-30! This year, the spotlight is on the synergy of data science with chemical biology. Save the date and keep an eye on chemical-biology.org for event updates. #ICBS2024 #chemicalbiology

Full text now out! Fantastic collaboration with EpiCypher, Inc. showing that nucleosome context matters for histone PTM readout, and that patterns of PTMs function both through direct readout and through conformational regulation eLife - the journal Department of Biochemistry and Molecular Genetics Department of Biochemistry and Molecular Biology
doi.org/10.7554/eLife.…

gofund.me/39c22f84

Really, a very interesting paper with elegant biochemistry. Upon binding to exposed dsDNA ends mimicking a double-stranded DNA break, PARP1 can multimerise at relatively low concentration into large isotropic complexes that manifest as condensates observable under microscopes.

Here it is! From preprint to published! Really proud of this study. Cannot recommend ⁦Molecular Metabolism⁩ enough. The peer review was fantastic and undoubtedly improved our work. Have a read if you care about histone lact(o)ylation! sciencedirect.com/science/articl…

Congratulations sancak ! Great to see this excellent work and resource out.

High-Throughput Identification of Calcium Regulated Proteins Across Diverse Proteomes biorxiv.org/content/10.110…

Back to back preprints showing mammalian SWI/SNF complexes regulate the transcription factor POU2F3 & represent a therapeutic vulnerability in small cell #LungCancer
1st, OserLab Cigall Kadoch
biorxiv.org/content/10.110…
2nd, Arul Chinnaiyan Christopher Vakoc
biorxiv.org/content/10.110…
(This…

2024 edition of our 'Hands On Summer School' Helmholtz Munich | @HelmholtzMunich. ATAC-seq, ChIPseq, CUT&Run, CUT&Tag 🧪 AND 💻.
Registration now open ! Spaces limited !
+ great speakers every day #epigenetics

Important update!!! The deadline for abstract submission to the CSHL Meetings PARP family and ADP-ribosylation meeting has been extended until Jan 31st.

Delighted to share our recent review 'Cytidine Acetylation Across the Tree of Life,' out now in Accounts of Chemical Research.

We detail this modification's history, chemistry to discover & study it, and our group's current perspective on the field.

pubs.acs.org/doi/10.1021/ac…

I'm happy if somewhat shy to share my review on protein PTMs: the history of PTM research, key paradigms, chemical & mechanistic principles, and hypotheses re PTM evolution. I thought a unified narrative like this might be interesting to some readers. onlinelibrary.wiley.com/doi/full/10.10…

Excited to be co-organizing the 2024 Van Andel Institute (VAI) Epigenetics Symposium July 8-10. This year's theme will be 'Cancer Epigenetics' with keynote lectures from Drs. Kristian Helin and Steve Baylin. vai.org/event/vai-epig…

Latest preprint from our lab. A shout out to DykhuizenLab and all other authors from the lab (not on X).
Activity-assembled nBAF complex mediates rapid immediate early gene transcription by regulating RNA Polymerase II productive elongation. biorxiv.org/content/10.110…

Please be sure to check you kid's candy this year. I just found another project I have no time for in a Reese's cup

Congrats Dr. Stephanie 'Billie' Heard Stephanie Billie Heard on your recent publication characterizing a fungal NRPS gene cluster! Excited to have collaborated with the Diehl Lab at UofU on this project! pubs.rsc.org/en/content/art…

Ever since graduate school, I sought a comprehensive lists of PTMs (including masses!) in the human body. Well, I believe Naoya and I have done exactly that. We hope this can be a starting point for any and all interested in PTMs! ⁦Biochemical Journal⁩ portlandpress.com/biochemj/artic…

“Women earn more than 50% of PhD’s, but receive only 39% of postdoc fellowships & 18% of professorships.[..] The more decorated a male scientist is, the fewer women he trains, and universities hire their junior faculty members from these elite men’s labs.”
theatlantic.com/ideas/archive/…

'Science, narcissism and the quest for visibility' - thoroughly enjoyed reading this one febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Our paper on atropisomeric triazoles written with and in memory of my late PhD supervisor John is out in OCF this week. With the front cover designed by the great man himself. JSF Group Ben Buckley
pubs.rsc.org/en/content/art…