It's been a long time since I've said this about a 53-tweet thread, but this is well worth the read for ppl interested in biology-adjacent research (concepts may generalize more broadly, but examples are biological). The figures in the thread go beyond the paper (but read both!).

Keith Wood is such an amazing scientist. ☀️ 🌸

Read this and read it again - I am!

This is just a small glimpse, but we are so proud of all of the hard work and fantastic research presented by our CCR fellows and staff at #AACR24 ! NCI Cancer Training 👏

You know you want one #TeamMassSpec bonfire.com/teammassspec20…

Wonderful visit to Duke University Chemistry! Great sharing science with old and new friends and soooo much RNA.

Thanks to my hosts Amanda Hargrove Derbyshire Lab @ Duke and all the students and faculty who took time to meet. BoyceLab MeyerLab Stacy Horner

Congratulations to current group member McKenna Crawford and lab alum Whitney Lieberman for being awarded NSF GRFP and NIH F31 fellowships last week! The group is so proud of you both. #PostbacsRock

NCI Center for Cancer Research

It was quite a ride.

Ben Cravatt ⁦Scripps Research⁩ delivers an inspiring master class on covalent chemistry, dramatically expanding the druggable universe ⁦AACR⁩ #aacr24 👏👏👏

WHOA

Have Astral, #FragPipe will travel! I downloaded the data from the Coon Lab 'one hour proteome' paper mcponline.org/article/S1535-…, KO vs WT (3 replicates). Great data. Even without using fractionated runs (direct DIA): 10050 proteins (9750 genes)/sample, followed by FragPipe-analyst.

Susanne Müller The SGC Frankfurt opening #AACR24 . Are you targeting your target protein? The importance of using high quality chemical probes in target validation studies. And to make use of best practice recommendations how to find & use them.

A huge congratulations to the #GRFP Awardees, Honorable mentions, and all applicants! No matter the outcome, you committed time, worked hard, and learned a lot during an extremely hectic phase of your education, and you should feel proud for pulling that off.

Getting older is when your kids pick up an old photo book:

“Look at your hair in this picture!”

“LOOK at your hair in THIS picture!”

Awesome new paper from Kathrin Lang. They use a clever protection strategy to mask the negative charge of acyl-CoA derived PTMs, allowing their function to be probed using genetic code expansion strategies.

Thioesters upon thioesters and a much-needed mechanistic tool! 🙌

Recalls the Yamamoto papers on DNA as an allosteric ligand tailoring TF transactivation potential:

science.org/doi/10.1126/sc…

Now: DNA as an allosteric ligand tailoring small molecule covalent modification potential?? Wild and beautiful work.

Been waiting years for this. Thanks for getting it done!