To the axon, RNA regulation, neurotrophin, and cytoskeleton nerds and nerdettes out there: Ta-dah!! :) (Summary thread coming soon). BDNF controls phosphorylation and transcriptional networks governing cytoskeleton organization and axonal regeneration biorxiv.org/content/10.110…

New BioRxiv paper on using cryptic splicing to unlock precision gene therapy activation for ALS, FTD & other TDP-opathies! Key contributions Max Z. Y. J. Chien Josette Wlaschin +many others from Claire Le Pichon ule_lab FrattaLab labs and more. A thread 🧵 1/13 biorxiv.org/content/10.110…

Want to deliver gene therapies broadly, but activate them only in diseased neurons? TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies. biorxiv.org/content/10.110…

Come work with us! I have a PhD position available to help understand which mutations in the non-coding parts of coding transcripts have functional consequences in Stem Cells. #phdjobs #Bioinformatics #genomics #miRNA findaphd.com/phds/project/w…

TDP-43 loss causes mis-splicing in ALS/FTD. We now show it also induces widespread cryptic 3'UTRs. This increases RNA stability, translation and function of ELK1 and other TFs. Also provides novel targets for biomarker and therapeutics development. biorxiv.org/content/10.110…

This work was led by Sam Bryce-Smith and a joint effort with Maria Secrier and many others. Parallel efforts from the Gitler and La Spada labs also identify the link between TDP-43 and 3'UTR changes and out now: biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out my lab's eighth annual Single Cell Genomics Day on March 29. Keynotes from IdoAmitLab Jason Buenrostro and Xiaowei Zhuang. Please RT/spread the word! satijalab.org/scgd

Many fully-funded PhDs available with me & Dr Ahmad Al-Khleifat Ammar Al-Chalabi Sarah Marzi (deadline:10th March):surl.li/reuti If you want to analyse multi-omics using ML & bioinformatics to study MND please check out project 21,26,57,58,62,65,74 EPSRC DRIVE-Health CDT in Data-Driven Health King's MND Centre

We're looking for someone with a creative mindset and excellent modern molecular biology skills (DNA manipulation, Illumina, Nanopore etc) to join our team at UCL and The Crick in the FrattaLab developing candidate gene therapies for ALS. Apply here: jobs.ac.uk/job/DGJ551/res…

New postdoc opportunity to work on splicing and ALS therapeutics The Crick and UCL Queen Square Institute of Neurology. Basic molecular work with true translational potential. 4 days still to apply. jobs.ac.uk/job/DGJ551/res…

📢Calling all UCL cancer researchers! Don't miss Dr Maria Secrier, Associate Professor in Computational Cancer Biology @UCL give the next Computational Cancer Collaboratorium seminar. 🗓️Tuesday 26 March 2024 ⏰11:30am -1:15pm 🗺️Cruciform Building, LT2 eventbrite.co.uk/e/ucl-computat…

TDP43 proteinopathy exhibits disease, tissue, and context-specific cryptic splicing signatures biorxiv.org/content/10.110… Really impressive work from Genentech

In order to further the development of an open database of scientific illustrations for the life sciences we have now set up a non-profit under the umbrella of @OC_Europe 1/ opencollective.com/bioicons

Still looking for a talented and enthusiastic bioinformatician to work with us on a super exciting project on DNA damage and RNA metabolism in motor neuron disease. PataniLab All details here: ucl.ac.uk/work-at-ucl/se… closing on 9th may! UCL Queen Square Institute of Neurology The Francis Crick Institute

Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? Google DeepMind

Final days to register to our symposium on the Spatial Biology of Cancer. Hear from leading experts in the field, and enjoy an exciting Hackathon! meetings.embo.org/event/24-cance… #spatial #biology #EMBO

We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A. Surprising effect of just one cryptic exon and promising strategy for ALS! Matt Keuss Pete Harley in great collaboration with Juan Burrone Lab biorxiv.org/content/10.110…

Muscles 💪 and AAV 🦠 - what more could you ask for? Our preprint highlighting strategies for effective transduction of skeletal muscle with AAV with Wenanlan @J_N_Slayer FrattaLab : biorxiv.org/content/10.110… UCL Queen Square Institute of Neurology UCL Brain Sciences UCL Div of Surgery The Crick UK Dementia Research Institute

Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in Science Magazine science.org/doi/10.1126/sc…

Out Science Magazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS. We do it by taking advantage of cryptic splicing. science.org/doi/10.1126/sc… UCL Queen Square Institute of Neurology The Crick Oscar Wilkins Max Z. Y. J. Chien