@frattalab : We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A. Surprising effect of just one cryptic exon and promising strategy for ALS! Matt Keuss @PeteHarley95 in great collaboration with @jbneuro biorxiv.org/content/150.110… • TwiCopy

FrattaLab

@frattalab

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FrattaLab @UCLIoN working on #RNA biology of #ALS and #SBMA and #Kennedy's disease

ID: 1190230623849459712

linkhttps://www.frattalab.org calendar_today01-11-2019 11:35:16

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FrattaLab

@frattalab

3 months ago

We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A. Surprising effect of just one cryptic exon and promising strategy for ALS! Matt Keuss Pete Harley in great collaboration with Juan Burrone Lab biorxiv.org/content/10.110…