This seems like an absurdly bad idea.... 😱 In the process of 'building herd immunity', a large number of high risk individuals (older people and those with underlying conditions) will die. #COVID19 theguardian.com/world/2020/mar…

7 days ago Italy had 1000 deaths and 12.8k cases. 14 days ago 148 deaths and 3.2k cases. 21 days ago 17 deaths and 588 cases.

broadwayworld.com/article/Andrea…

Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe #COVID19 and the presence of clonally expanded CD8+ T cells in those with moderate COVID-19. go.nature.com/2Z2y5G1

Here is the transcriptomics insight: the bulk RNA-seq (Fig 1), single-cell RNA-seq (Fig. 2), spatial transcriptomics (Fig. 3), and the original organ (Fig. 4). (Feel free to cite with image credit to Bo Xia)

Inflammatory Bowel Disease Through the Lens of Single-cell RNA-seq Technologies academic.oup.com/ibdjournal/adv…

For the development of cytokine-targeting biological therapies for treatment of inflammatory diseases - Three Scientists Awarded the 2020 Tang Prize in Biopharmaceutical Science - C. Dinarello, M. Feldmann & T. Kishimoto. All ICIS Honorary Lifetime Members tang-prize.org/en/media_detai…

Great collaboration between Cleveland Clinic, Case Western Reserve and @MRC_HIU (University of Oxford) JCI - Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis jci.org/articles/view/…

I am very excited to announce that our paper is now online ⁦Nature Medicine⁩ . Here we conducted the first atlas of colonic CD8+ T cells in health and IBD utilising multi-modal single cell technologies and defined their contribution in inflammation nature.com/articles/s4159…

Single-cell profiling reveals heterogeneity of colonic CD8+ #Tcells in patients with ulcerative #colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features Daniele Corridoni @MRC_HIU MRC WIMM Nuffield Department of Medicine go.nature.com/3kabyyS

Delighted to announce that the primary endpoints in our Phase 2a, randomized, double-blinded, placebo-controlled study have been met tinyurl.com/yyeahlrm #KY1005 #AtopicDermatitis

Proud to support a reliable and trustworthy scientific record as a #PeerReviewer! #PeerRevWeek20

Congratulations to Professor Alison Simmons, who has been appointed as Director of the MRC Human Immunology Unit @MRC_HIU. More: orlo.uk/XEAP9

We are pleased to announce that Prof Alison Simmons has been appointed as the new Director of the @MRC_HIU, starting from the 18th Jan 2021. Based in the Unit since 2007, the Simmons group investigates how the immune system functions in the intestine. imm.ox.ac.uk/about/news/mrc…

Interesting interview with Aviv Regev about her move to Genentech: How to deliver better medicine? 1. human biology, 2. high-res methods, 3. modalities, and 4. computation & maths, the latter for "predictive, generative and interpretable models". nature.com/articles/d4157…

.RDM Oxford, OUH researchers provide an in-depth look at how skin - much like the #gut - maintains a healthy #microbiome, revealing a previously unrecognized bacteria-sensing role for immune cells called ILC2s residing in this barrier organ: immunology.sciencemag.org/lookup/doi/10.…

With more than 100 currently in clinical development, bispecific antibodies have emerged as molecules with a multitude of talents. Learn more in a new #SciencePerspective: fcld.ly/5yzuym6

Thank you to Daniele Corridoni from Kymab Ltd for talking to our students about drug discovery without borders in the careers section of todays symposium.

Now online! GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis dlvr.it/SGzm7g