Biological data is being generated at a staggering rate. AI will be instrumental in making sense of it all. Looking forward to exploring this topic with Stephen Wolfram and Moira Gunn at @synbiobeta on 5/7. #SynBioBeta2024 bit.ly/4cQNZ9E

With his “somehow both frenetic ⚡ and California laid-back 🏄” energy, #CZBiohubSF President Joe DeRisi makes San Francisco Chronicle's inaugural 'Influence List'!

Check out how Joe and other influencers are shaping the future of San Francisco (paywall):
bit.ly/3WhwERH

From building his own computer as a kid to engineering novel cancer-detecting technology, Daniel Wang has developed a knack for coming up with creative ways to use tech to solve biological problems.

Get to know the first group lead of #CZBiohubCHI ⤵️
bit.ly/3W5zLfn

To overcome the challenges of volumeEM adoption, VolumeEM is working to:
📕 Build effective resources
🌎 Strengthen & expand the global community
🔉Conduct outreach & dissemination + more

Through cross-species #SingleCell analysis, Ben Cosgrove is uncovering new gene regulatory mechanisms that could lead to breakthroughs in treating pediatric skeletal muscle disease

Optical pooled screens combine high-content imaging with in situ sequencing to identify genes that affect phenotypes like morphology + subcellular localization.

Collaborators Jain, Lagier-Tourenne + Blainey Lab are using this tool in human iPSC models of ALS

#RareAsOne grantee Rare Cancer Research Foundation + Pattern.org is helping rare cancer patients donate their tumor tissue so researchers can make cancer models to study genetic changes + find therapeutics

Neuroscientist Alejandro (Alex) Chavez + team are working to better understand neurodegenerative disorders using in vivo CRISPR screens.

Here you can see Purkinje cells 🟢🔴 residing in the dense folds of the mouse cerebellum

By imaging iPSC-derived neurons with multicolor microscopy, #NDChallengeNetwork grantees @DeshmukhLaB, Sarah Cohen + @syeung10 hope to simultaneously capture multiple organelles in action in living cells

I am deeply saddened by the passing of Lubert Stryer, a terrific friend and mentor. Our first recruit at #CZBiohubSF , he led the inaugural investigator competition and established a culture of scientific excellence and collegiality.
He was a remarkable scientist and human being.

The research data our #RareAsOne grantees are helping create + the patient communities they are building could power AI in our fight against #RareDisease bit.ly/4aWPGk9

This year’s Breakthrough gala celebrates groundbreaking achievements that are transforming science—from key advances in the fight against 3 major diseases to deep insights into quantum field theory & differential geometry. Congrats to all the laureates!

🌍🔬 CZI's renewed support launches our journey into the next era of imaging exploration! See the full Press Release & watch GBI's Impact Video🚀:
globalbioimaging.org/news/renewed-s…

Australian National Imaging Facility BioImaging North America Microscopy Australia Euro-BioImaging ERIC Latin America Bioimaging South Africa BioImaging African BioImaging Consortium ABiS

A collaboration between Leonel Malacrida, Dr. Elizabeth Head, Xiaoyu Shi + Tatsuo Fukagawa developed Label-Retention Expansion Microscopy (LR-ExM), which uses novel chemical probes for deep tissue super-resolution microscopy with conventional fluorescence microscopes at low cost

We’re thrilled to welcome our Science Diversity Leadership grantees to CZI HQ! Over three days, scientists are leading panels + giving talks on how their labs are accelerating research across biomedicine

#DiversityInSTEM

In their @NaturelCellBio publication, Uri Manor 💔 + Gerry Shadel’s groups propose a new model for endosome-mediated removal and disposal of dysfunctional mtDNA nucleoids, with implications for studying pathogenic inflammation & aging bit.ly/3STfojl

How do diverse cardiac cell types organize into the complex structures required for heart function?

Using #SingleCell + MERFISH, researchers Quan Zhu & Neil Chi developed a spatial map of heart cell development & interactions in @nature: bit.ly/3TwZqe1

By developing an in vivo CRISPR screening method, Alejandro (Alex) Chavez + team will study the impact of mutations in 100s of different genes at the same time, within a single animal.

In doing so, they hope to uncover determinants of neurodegeneration like spinocerebellar ataxia