What is striking about this is how SMALL the increase in odds of success is (2.6x is a small gain really)

And all the biggest drugs of the 21st Century have no real genetic target validation (statins, Plavix, Humira, PD(L)1s, Comirnaty, GLP1s and others)

So excited to be recognized as one of the 502 AAAS Fellows for 2023. Such an honor for me, that could not have happened without my lab members and collaborators!

Can not studying popular genes cost you your career?!
Check out how the probability of a junior scientist to transition to a principal investigator is lower if the genes they research are less studied. The overall decreasing probability is also really depressing! (from Fig. S10)

One key point here: avoid the classic trap of pursuing academia to exhaustion, and *only then* starting to consider other options. This approach means making decisions when you are desperate and have reduced leverage.

We had the privilege of hearing some of the ways Beth Cimini 🔬💻 📊 and the members of the Beth Cimini Lab 🔬💻 📊 approach analysis of microscopy images in a special seminar! Title slide font brought to you by #papyrus in honor of the snl skit sequel

Congratulations to Yoshua Bengio on being named one of TIME 's most influential people. Yoshua has not only been an advisor to $RXRX, he’s a pioneer, a mentor and believes in the power of #AI to help industrialize #drugdiscovery .
#techbio #TIME100 time.com/6964962/yoshua…

1. Who chooses to spend $800,000+ to help Trump become the next president?

We got a peak this week when a new joint fundraising committee, Trump 47, filed its first FEC report

The filing revealed 20 people have donated $800,000 or more

Follow along for the gory details

🧵

Colleagues who are PIs: what is the likelihood of you accepting a seminar invitation from trainees (versus a seminar invitation from a colleague)?

Does it matter if it’s a junior or senior colleague?

(This is for departmental seminars only not conference invites)

🧵 Should academic researchers collaborate with a known or suspected harasser?

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

College admission essay content has a stronger correlation with household income (R2 = 16%) than SAT scores.
This explains how removing standardized tests can increase inequality.
Based on 240,000 admission essays to the University of California. science.org/doi/full/10.11…

The frequency of use of the word 'unqualified' in student reviews of women teaching engineering is so high compared to that for both men and women in other disciplines that it barely fits on the graph. Lads, do you really think unqualified women get to teach tech at universities?

For the first time ever i'm going to have to give $$$ back to NIH. They just disallowed our NCE request

I was too cautious with the $ due to the pandemic. According to the National Institutes of HEALTH, COVID conditions have now 'normalized' and are not extenuating circumstances

I am predicting Biorender will amend their terms in the next few days. If you cannot preprint to bioRxiv anything with Biorender figures in it, EVEN AFTER PAYING, I cannot see how they’ll ever stay in use, let alone in business.

Join us for the ML for Drug Discovery Summer School, where we'll have talks and tutorials from Yoshua Bengio, Anne Carpenter, PhD, Michael Bronstein, Pratyush Tiwary, Bharath Ramsundar, Connor W. Coley and many more.

Probably The Real Steve Mang 🚲 you must be on some list students have. lol. I wish I was on one because I would love to have high school students work in my lab, but don't have the time to search for them.

NEW: my column this week is about the coming vibe shift, from Boomers vs Millennials to huge wealth inequality *between* Millennials.

Current discourse centres on how the average Millennial is worse-off than the average Boomer was, but the richest millennials are loaded 💸🚀

I'm still dissecting my strongly negative knee-jerk reaction to this announcement, but there's something I clearly don't understand: When high school students do research, which is a thing I just learned in the comments apparently happens, who is advising them?