Our new study out today in Science Translational Medicine identifies a TREM2 R47H-specific microglial subpopulation in human AD brain and tauopathy mice, reminiscent of DAM and AKT hyperactivation which can be rescued by pharmacological AKT inhibition. science.org/doi/10.1126/sc…

We’re excited to share our latest research out in Cell TODAY! Using APEX and AP-MS proteomics, we mapped Tau interactomes that were modified by neuronal activity and FTD mutations in hiPSC-derived neurons. Check it out👉sciencedirect.com/science/articl…

Our latest research reveals microglial NF-κB activation drives tau spreading and toxicity in tauopathy mice. Inactivation of NF-κB reversed tau-associated microglial states and functional deficits. Wonderful collaborators@AMCuervoLab@grinberg_t nature.com/articles/s4146…

A new preclinical study led by Dr. Li Gan (@liganlab), Dr. Wenjie Luo (Wenj) and #WCM researchers suggest that targeting a signaling pathway in brain immune cells could slow the progression of Alzheimer’s and other neurodegenerative diseases: bit.ly/3uFS9x6

Our collaborative work with Martin Kampmann is out today in Nature Neuroscience! We devised a fast and efficient method to generate induced #microglia from #iPSCs and developed #CRISPR i/a platforms to study regulators of microglial states in health and disease. nature.com/articles/s4159…

🎉🎉Congratulations to Gillian Carling, PhD, who received the NoA for her F31! So excited for your innovative research on the TREM2-APOE pathway to be recognized! Way to go! 🥳

My favorite C57Bl/6 colony ❤️ Happy Halloween from the Gan Lab lab!! 🎉🎊🍬🍭💕☺️👻🎃

Friend turned foe? Our insight article commenting on the exciting work from David Holtzman about TREM2 agonist antibody exacerbates tau seeding in 5xFAD mice (Jain et al. JEM), pointing at the importance of timing for TREM2 agonist antibodies in treating AD. rupress.org/jem/article/22…

Our latest study is out today in Nature Neuroscience. We report that tau-activation of cGAS in AD diminishes cognitive resilience by decreasing the neuronal transcriptional network of MEF2C through type I interferon (IFN-I) signaling. (1/6) nature.com/articles/s4159…

Wishing you a spooktabcular Halloween🎃👻 from the entire Gan lab!

Gan Lab in SFN 2023, DC (2): enjoying scientific social in neuroscience community and fun lab gathering.

Check out our latest study on BioRxiv🎉! Delving into the strongest AD risk factors, we unveil cell-autonomous microglial cGAS-STING signaling, along with cGAS-dependent microglial senescence in female tauopathy mice carrying both APOE4 and TREM2R47H. biorxiv.org/content/10.110…

Happy to contribute a new perspective on a key modulator of mechanisms underpinning #Alzheimers: sex! Biological sex affects immunity, metabolism, and the microbiome through well-known players such as NF-kB and TREM2 ➡️sciencedirect.com/science/articl…

Thrilled to announce our latest work in Cell! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/… (1/5)

Super excited to announce our latest work in Molecular Neurodegeneration! We generated new anti-acetylated-tau-K174 antibodies that effectively mitigate neurobehavioral impairments and reduce pathology in PS19 mice— alone and in conjunction with TBI. (1/5) Details here: bit.ly/4bbKokA

Congratulations, Dr. Gillian Carling! Yesterday Dr. Carling successfully defended her thesis on the combined role of TREM2 and APOE4 in cGAS-associated senescence and neurodegeneration in AD. Your hard work these past 5 years has paid off, Dr. Carling!🥳 Gillian Carling, PhD WCM Brain and Mind Research Institute

We're excited for our latest work published in @Neuron! We explored the impact of Alzheimer's risk factors APOE4 and TREM2-R47H in a tauopathy mouse model, revealing elevated microglial cGAS-STING signaling and senescence in females with both risk factors. cell.com/neuron/fulltex…

Drs. Gillian Carling, PhD, Li Gan, et al. Weill Cornell Medicine found that two genetic variants, that confer high risk of #Alzheimers, together trigger harmful inflammatory response in brain’s immune cells, particularly in females, in preclinical model Neuron cell.com/neuron/fulltex…