I am very grateful to the YoungEHA committee for this opportunity to share this great collaborative work from the Schuringa Lab, #RegoLab, and Myeloid Leukaemia Genomics and Biology Group on metabolism in AML! Looking forward to the next talks at #EHA2024!

Fantastic talk from Jan Jacob Schuringa on the latest data from the Schuringa Lab about the metabolic heterogeneity in AMLs and the role of the tumor microenvironment on metabolic abnormalities/adaptation in AML at #EHA2024!

Amazing talk summarizing all the old and new directions regarding mitochondrial/lipid metabolism in drug resistant AMLs from Sarry Lab at #EHA2024!

Finishing #EHA2024 with this amazing opportunity to present our latest results on MN1-driven AMLs! Very grateful to the European Hematology Association scientific committee, to my mentor Jan Jacob Schuringa and all the members of the Schuringa Lab, Myeloid Leukaemia Genomics and Biology Group and #RegoLab that contributed to this story!

Wish you could quickly analyze your #singlecell data? Or easily share these large datasets with collaborators? Good news! We just launched our free web-based app 10x Genomics Cloud Analysis globally! Sign up now or explore a guided walkthrough: bit.ly/4cpHhae

This is everything.

WE’LL NEVER FORGET THIS MOMENT 🥹 An all-Black podium graces #OlympicGames gymnastics for the first time ever.

🔎 Investigators with Dr. Vilma Dembitz at Barts Cancer Institute (Queen Mary) identified stearoyl-CoA desaturase as prognostic of patients' outcomes and showed that SCD inhibition ⛔ is a therapeutic vulnerability across multiple #AML models. Leukemia Journal | go.nature.com/4g44ssH

CH in Telomere biology disorders as predictors of #MDS! As Chr1q+, U2AF1-S34 leads to TP53 pathway deregulation in HSCs with dysfunctional telomeres. Now online! #TBD #clonalHematopoiesis

Why do AML patients with African ancestry have poor outcomes? Fascinating results indicate that genetics alter AML biology. Also, its Bailee Kain's first co-first author postdoc pub. Bailee Kain AK Eisfeld Nathan Salomonis and Elaine Mardis nature.com/articles/s4158…

I’m excited to share an R package that we’ve created for mapping scRNA-seq data across normal and malignant hematopoiesis! We've used this to identify hematopoietic stem cells from healthy tissues and map leukemia cells from hundreds of patients. 1/6 github.com/andygxzeng/Bon…

We are at the #ASH2024! Check out today poster #1393 about the role of lipid metabolism in metformin sensitivity in AML from Dominique Sternadt and #1539 with the mechanisms of MLL5-driven leukemic transformation from Luíse Simões

Great ending for the first day at #ASH2024 with this group that keeps growing every year! Great to see you all! Schuringa Lab Myeloid Leukaemia Genomics and Biology Group

Fantastic talk from Manuela at #ASH2024 on the role of autophagy in FLT3-inhibitor therapy in AML! Great collaboration of the Traina Lab at FMRP USP and Schuringa Lab ! Very well done!

So happy to present our work at the #ASH24! I’m very honoured to be a recipient of the abstract achievement award this year. Many thanks to all the collaborators involved in this project Schuringa Lab Myeloid Leukaemia Genomics and Biology Group FrezzaLab Sarry Lab

Fantastic talk from Dr. Zheng from the Myeloid Leukaemia Genomics and Biology Group on the role of TP53 mutations in CH-associated dyserythropoiesis and OxPhos alterations!

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!

Register now for the FEBS Workshop on the Molecular and Cellular Pathways of Aging in Hematopoiesis that will take place in Crete on October 20-24, 2025! To register visit: …inginhematopoiesis2025.febsevents.org

Review from the lab on lipid metabolism in AML just out Leukemia Journal rdcu.be/em651 Led by the hard work of Vilma Dembitz and Sophie James Hope you enjoy the read!

Excited to announce a new paper in Cancer Discovery with Junwei Shi, Zhendong (Tom) Cao, Anthony Daniyan and led by Pu Zhang. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in AML: aacrjournals.org/cancerdiscover…