1/ How does one compare mouse networks to humans? Are networks implicated in rodent models of psychiatric disorders the same as in humans? Can a mouse brain be fitted into a human brain? In our latest paper, we provide some clues: rdcu.be/czvsG

What's wrong with my experiment? New Review in Neuropsychopharmacology discusses - and provides recommendations - on which variables to report in publications and how to address “hidden variables” that impact results @trainorlab Amanda Kentner Hanna Butler-Struben nature.com/articles/s4138…

Proud to have spent my undergrad and postgrad at Monash Pharmacy & Pharmaceutical Sciences (also hi mum & dad I'm famous) | Monash ranks number one in Pharmacy and Pharmacology - 2022 QS World Uni... youtu.be/kc6FCVh0Lt4 via YouTube

New open access paper out in molecularpsychiatry using PET-MR to investigate relationships between glutamate, dopamine, & cortical gray matter. With Antoine Rogeau, Sameer Jauhar and Matthew Nour. nature.com/articles/s4138… 🧵1/n

Antipsychotic Efficacy of KarXT (Xanomeline−Trospium): Post Hoc Analysis of Positive and Negative Syndrome Scale Categorical Response Rates, Time Course of Response, and Symptom Domains of Response in a Phase 2 Study psychiatrist.com/jcp/schizophre…

Female mice are less variable than male mice once again! bsd.biomedcentral.com/articles/10.11…

WOW!! 'Our data show that exposure to male versus female experimenters’ scents induces differential behavioral responses and alters responses to antidepressant-relevant doses of KET in mice.' nature.com/articles/s4159…

Online today Biological Psychiatry a perspective I co-authored with Valerio Zerbi 👏on the use of rodents to model & study brain dysconnectivity ➡️tinyurl.com/2dyvbhyn This is part of upcoming special issue on biological mechanisms of human brain dysconnectivity (more soon!)

📢📢NEW PAPER from the lab! Combining #optogenetics and #fMRI is opening up new avenues for research into polysynaptic functional networks. Here we openly share our most detailed protocols and step-by-step instructions for doing opto-fMRI in rodents! sciencedirect.com/science/articl…

A game changer for neuroscience: MRI with millisecond precision. Out now in Science Magazine science.org/doi/10.1126/sc…

Final version of Kristina Sabaroedin 's fab review on the role of cortico-striatal circuitry in psychosis, w/ J Tiego, now out in Biological Psychiatry: biologicalpsychiatryjournal.com/retrieve/pii/S…

" to accelerate development of targeted therapeutics ... regulatory agencies and the pharmaceutical industry must embrace ...trials focused on pathophysiologic pathways that impact specific symptom domains in subsets of patients, agnostic to diagnosis.' nature.com/articles/s4138…

Rebranding as Dr Spark

Important study for neurosci field. Shows that the push to study males and female rodents (of a single strain) is misguided, and arguably leads entire fields to draw erroneous conclusions about sex differences. Sex differences in C57Bl/6 mice do not generalize to other strains.

Are there glutamate subtypes in schizophrenia? (eg treatment resistant vs responders). If so, we'd expect to see increased glutamate variability in patients compared to healthy volunteers. This is what we looked at in this meta-analysis (1/) nature.com/articles/s4138…