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Proud of this work led by Alessandro Gozzi (@gozziale.bsky.social) and Marco Pagani following 10y or r&d, massive multi-labs collaborations and lots, lots of scans. See the inspiring 🧵 below 👇🏼

Report: fMRI of 20 mouse models of autism (n=549 mice) clustered as hypo- & hyper-connectivity subtypes. In human autism (940 cases; 1036 controls), 25% had analogous hypo-/hyper-connectivity subtypes. Will be interesting to learn developmental timing & environmental effects.

Our latest work is online today Science Advances ➡️Brain connectivity in carriers of high risk mutations for #autism and #schizophrenia U-turns across adolescence (hyper -> hypo) ➡️This switch is driven by synaptic remodeling science.org/doi/10.1126/sc… Full explainer below 👇

1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word! biorxiv.org/content/10.110…

Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025.0… We hope this method is useful to a wide range of the biology community.

There are two subtypes of autism: brain hypoconnectivity & hyperconnectivity. 🧵1/9

Outcomes for the first 60 MDD patients treated at our clinic Queensland Neurostimulation Centre with robotically delivered & fMRI-personalized rTMS MADRS response=74%, remission=53% for RCT patients EXCITED to see fMRI moving from research to real-world clinical use! karger.com/pps/article/do…

#Puberty may alter #BrainConnectivity in chromosome 22q11.2 #DeletionSyndrome, increasing autism and schizophrenia risk. Changes in synapse density and GSK3-beta protein are key factors, mouse study indicates. Science Advances doi.org/g9d6zj medicalxpress.com/news/2025-04-p…

Breathing isn’t just for life—it’s a brain pacemaker! This excellent review reveals how each breath sends sensory waves that globally synchronize neural networks - with implications for "functional connectivity". Congrats to the authors! 👉 doi.org/10.1038/s41583…

Nice to see our preprint featured! Thanks Calli McMurray and The Transmitter for the excellent coverage!🐭🧠 👇 #neuroscience #autism

After a long journey, our paper is officially out in PNAS! 🚀 Huge thanks to the team — excited to finally share it with the world. Check it out: pnas.org/doi/10.1073/pn…