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Research | Heiko Lickert, A Böttcher & Fabian Theis (Helmholtz Diabetes Center (HDC)) use #singlecell approaches, lineage tracing & metabolomics to characterize intestinal stem cell changes in response to an obesogenic diet in mice. nature.com/articles/s4225… rdcu.be/cyJZb

For readers interested in engineering islets to provide therapies for diabetes, here's a comprehensive recent review by Heiko Lickert and colleagues rdcu.be/czIGy

Tissue clearing yields cool 3D images but not much molecular data. Not anymore🤗 Meet DISCO-MS enabling unbiased proteomics profiling of 3D-imaged organs. biorxiv.org/content/10.110… We co-developed with Matthias Mann Lab work by Harsharan Bhatia & Andreas-David Brunner collab. with Fabian Theis🧵👇

In 1928, Alexander Fleming discovered the mould he was working with produced a substance that could kill many common bacteria. He called this new, exciting substance "mould juice". Only after a couple of months did he name it penicillin. #WorldAntibioticAwarenessWeek

Wonderful summary: “New insights into β-cell failure, regeneration and replacement.”

The skull is considered a physical barrier (helmet) for the brain. Our new findings show that the skull can be utilized to interact and monitor neuroinflammation in diverse brain diseases. #scRNAseq #proteomics #skull #AI #clearing #TSPOPET biorxiv.org/content/10.110… details🧵👇1/n

So happy that CellRank is finally out Nature Methods: Led by Marius Lange in collab with the wonderful dana_peer, we’re learning single-cell fate maps from scRNA-seq & RNA velocity. Many additional example&improvements vs preprint, please check it out at go.nature.com/3Fm17lt

Our paper on building first drafts of a human lung cell atlas out in ERS publications. discovAIR Horizon2020Projects Helmholtz Munich | @HelmholtzMunich Human Cell Atlas Martijn Nawijn

CellRank for unbiased discovery of unexpected regeneration trajectories including airway cells...

Great review from Chirag Chirag Jain, Ansar Ansarullah and Sara Sára Bileková on beta cell targeting in Nature Metabolism today - congratulations 🎉🎊🍾

Great opportunity to do some cool science…Check this out 👇

I am glad that our new vDISCO article (nanobody labelling of whole mouse) made the cover of Nature Protocols😃. Work by Ruiyao Marika Cai Ilgın Kolabas and Chenchen Pan et al. doi.org/10.1038/s41596…

TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease | Science science.org/doi/10.1126/sc…

Finally out, was waiting to read it. This was for sure one of the most provocative talk at #EISG2024, quite surprising, check it out 😉Regulated and adaptive in vivo insulin secretion from islets only containing β-cells | Nature Metabolism nature.com/articles/s4225…

Congratulations to the Inceptor team 🎉🎊🤩👏🏼 Happy to have contributed to this story 😊