#FeaturedProtocol this week is a full-body staining, clearing and #imaging protocol that enables the detection of #fluorescentproteins in entire #mice at cellular resolution go.nature.com/3HoEbES #tissueclearing

Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By HongchengMAI Jie Luo biorxiv.org/content/10.110… 🧵👇🏼(turn on the sound)

Some people talk a lot about sustainability and recycling, we do it! In our lab 2/3 of used plastics (mainly falcon tubes for ON cultures and plasmid isolations, spectrophotometry cuvettes etc.) are washed, autoclaved when needed, and used repeatedly..it's easy and it works fine!

📢Wrote this letter on visa inequity & inclusion in response to nature editorial on reforming Phd training + role of world & institutional leaders. NIH could consider this piece to re-envision postdoc training & career progression.🧵 Read here: rdcu.be/c6AQo 👇👇

We are hosting Brains & Bites in Menlo Park on Apr 4th featuring Ruiyao Marika Cai and Sven Truckenbrodt on advanced microscopy sample preparation technologies. Join us! lu.ma/brainsandbites6

🚨📢 Now out in Nature Biotechnology: The most fun #Microscopy 🔬 paper I've ever written with Fritjof Helmchen: The Schmidt objective - taking inspiration from 🔭 telescopes and 🐚 scallops to rethink the design of #multiimmersion #microscope objectives: nature.com/articles/s4158…

😮~60% of us who had COVID still might have lingering viral spikes in our heads! Our new study reveals SARS-CoV-2 spike accumulation in the skull-meninges-brain axis & its implications in long COVID. By Zhouyi Rong HongchengMAI Saketh Kapoor, PhD🔬🧠🦠🧵👇 biorxiv.org/content/10.110…

Our paper made the cover!! 🎉 Ruiyao Marika Cai Chenchen Pan Ali Max Erturk wohoo Curious to see what happens on the whole body level after a disease or a perturbation? Then check out our vDISCO protocol paper to learn how to label&clear&image an entire mouse 👇🏻

An antibody specific to neurons provides a visualization of different levels of the peripheral nervous system in a whole mouse. scim.ag/2p9

Want to use deep learning for image analysis but lack the coding skills? We introduce DELiVR, a game-changer in brain-wide cell analysis. No coding required, our Fiji Plug-in does the magic. Hats off to Doris Kaltenecker, Rami, @[email protected]! 🧵👇🏼 1/n biorxiv.org/content/10.110…

The paper is out! We describe the next-generation open-source "Benchtop" mesoSPIM light-sheet microscope, with open access to everyone. Find the detailed blueprints on how to build your own, and examples of applications, from neuroscience to astrophysics! link.springer.com/article/10.103…

Absolutely thrilled to see our paper on a VR-trained deep learning pipeline for mapping mouse brain cells published in @NatureMethods 🤩 Retrainable via Fiji for custom data, we used it to study brain activities in cancer.

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵biorxiv.org/content/10.110…