My friend Darren Aronofsky texted me this earlier and my draw dropped. He told me it was AI. Lux is deeply invested in AI (esp Runway) but had he not told me I would have thought he made the movie in stealth and had no idea.

The largest randomized trial of medical A.I. —Over 100,000 women in Sweden —radiologist + AI vs 2 radiologists, in follow-up —AI added led to 29% more cancer detected, 44% reduced workload, and —Less cancer dx in subsequent 2 years, and, when found, less aggressive

Autonomous research agents that know when to stop. We set BIOS to run up to 20 iterations on a metabolomics dataset. It stopped after 2. Why? It found something significant enough to interrupt itself and ask the researcher what to do next. The agent identified pipecolic

Trying to join Moltbook as a human

you pity the moth confusing a lamp for the moon, yet here you are confusing a screen for the world

"The wealth taxi is moving to Miami." — typo in an email from Ron Conway about all the founders who are leaving California because of the proposed wealth tax

(3) We proved at Mako Surgical and Magic Leap that (a) you can build world class high-tech/deep tech manufacturing in the US, and (b) we did it in South Florida - attracting thousands of the best and brightest to the region.

Delighted to share new Arc Institute work from our group on AI-accelerated lab-in-the-loop, in Science Magazine today One of the most remarkable things about biology is that it's digital. DNA, RNA, proteins: these are all sequences, and their function is directly encoded in

Polymaths will dominate the next 5 years, but only if they practice the skill of knowing what to ignore. You can learn and do anything now, meaning that it will become increasingly rare for a person to put time, attention, and care into one thing.

steve jobs gave everyone a bicycle for the mind but forgot most people don't have anywhere to go

The most European thing imaginable. Monitoring the situation! (next week Monday)

It's a surprisingly useful heuristic to ask startups what would happen in a sci fi novel about them. It doesn't just work for product ideas but even for names: today we found a new name for a company by asking what it would be called in a science fiction story.

the most underrated hire right now is a great product person. when i say product person i'm def not talking about a product manager. perhaps i think there has to be somewhat of a new role. i don't have a good name for it yet but maybe something like "product thinker".. someone

knowledge asymmetry is no match for agency and curiosity in this era.

Collective intelligence > superintelligence

Convinced a majority of investors today would still fumble on getting to conviction on Apple at seed. A lack of imagination on market sizing & heretic founding teams potential can lead to regret. Take a swing on extraordinary desirable products the power law is on your side.

We spent decades optimizing supply chains for cost. Now we have to rebuild them for biology. ARPA and technologists will have to moonshot solutions to remove microplastics from the human body. Meanwhile “health” products are still sold in cans and plastic bottles. Let’s build

Microplastics and nanoplastics were found in 100% of healthy brains, 99.4% of diseased brains, with much higher concentrations adjacent to brain tumors nature.com/articles/s4436…

Wearables aren’t just for tracking you in real time They’re building your personal baseline The numbers you see today become the targets you’ll aim to return to decades from now