When it rains it pours! Congratulations to Chintan Patel, a graduate student in the lab, for receiving an 8% on his F31 training grant!!! Chin will be studying molecular mechanisms of presynaptic transmission in hiPSC-derived neurons using cutting-edge optical and EM techniques.

Congratulations Alejandra Romero-Morales, Ph.D (she/ella) for receiving a 5% score on your NIMH F32 training grant to study the role of TCF4 in human #oligodendrocyte development.

Hand here’s the official reveal: part 2 of my almost joint PhD thesis with Andreas Pfenning and Ryan Logan 🧠 21. co-led by the amazing Dr. Maddie Ray. Check out what cross-primate conservation of single cell damage in OUD.

nature.com/articles/s4146…

Thanks Pitt Hopkins Research Foundation and UPenn Million Dollar Bike Ride by ODC for selecting our grant for funding!!!! We can’t thank you enough for the continued support of our research program. #PennMedMDBR2023

We can't thank you enough for your support in 2023, which has been a year of growth for the PHRF!
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#PittHopkins #research #happynewyear24 #hope #raredisease

Finishing #SfN23 strong! 💪🏻

Catch Maher Lab’s amazing graduate student Norah work on Genetic and Pharmacological Rescue of #myelination in Neurodevelopmental Disorders.

Stop by PSTR450.22 (B49) today from 8am - 12pm to learn more!

Lieber Institute Society for Neuroscience (SfN) #womeninSTEM

Mark your calendars!

Thanks Pitt Psychiatry for the opportunity to present my labs work on Pitt-Hopkins Syndrome, ASD, and schizophrenia. It was great to meet and learn from your faculty members today. Cheers!

Here is a link to access our manuscript for free for 50 days. Thanks Elsevier for helping us share our research! authors.elsevier.com/a/1hviD1S07qKJf
Pitt Hopkins Research Foundation Pitt Hopkins Research FoundationUK PittHopkins Syndrome

Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes dlvr.it/SwmqTD

Proud to present my groups latest publication on the ASD risk gene TCF4, out today in molecularpsychiatry Congrats and many thanks to Huei-Ying Chen who led this project, and the many current and former lab members who contributed. nature.com/articles/s4138…@ . .

I think this is my 'final' publication w/ the Maher Lab and Brady J Maher Huei-Ying Chen. Prove me wrong! tinyurl.com/tcf4inhs Andreas Pfenning

Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes

I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with Jason Stein, Sri Kosuri, Michael Love, Jose Davila Velderrain, Brad Ruzicka, Alan Boyle. 🧵 follows.

So thrilled to share this incredible work from Maher Lab at Lieber Institute. Thank you Brady J Maher and team!

biologicalpsychiatryjournal.com/article/S0006-…

Ecstatic to announce our latest paper is out in Biological Psychiatry on Pitt Hopkins Research Foundation ! Special thanks to Brittany Davis who led this work along with the many current and former maher members and collaborators Luikart Lab and MadhaviTippani and Andrew Jaffe
biologicalpsychiatryjournal.com/article/S0006-…

Bohlen et al. show that promyelinating drugs reduce myelination defects and rescue behavioural and electrophysiological deficits in a mouse model of Pitt -Hopkins syndrome, an autism spectrum disorder caused by autosomal dominant mutations in TCF4. tinyurl.com/vbnmfs2e

“We’re not saying myelination is the only problem. This is just one piece of the puzzle and maybe something that would be easy to help,” says Brady J Maher.

bit.ly/3IHKjtA

Drugs that boost production of the neural insulation myelin might help children with Pitt-Hopkins syndrome, a new mouse study shows. Could a clinical trial be next?

By Laura Dattaro.
bit.ly/3WxvhvY

Yay 🎉🎉🎉! I'm so excited to be able to do science with such a supportive team! Thank you Maher Lab Brady J Maher and MSCRF 😊

Maher lab had some fun celebrating Alejandra Romero-Morales, Ph.D (she/ella) postdoctoral fellowship funding by the MSCRF Congrats Ale!!!! mscrf.org/awardees