I'm excited to share our work on quantifying the causal impact of biological risk factors on healthcare costs! Here are some highlights from our study. (1/n) medrxiv.org/content/10.110…

Hi all, very glad to announce our paper on “Mono- and biallelic variant effects on disease at biobank scale” is now finally published @nature in a set of 7 papers revealing scientific discoveries with FinnGen. nature.com/articles/s4158… Read on for a twitter summary 1/8

BOOM! Our genes influence which medications we are going to use in our lives! Our study on genetic predictors of lifelong medication use in cardiometabolic diseases finally out and published in Nature Medicine nature.com/articles/s4159…

New preprint! 10% of women lose one X chromosome in a fraction of leukocytes. What’s the cause/consequence? We leveraged genetic data from 904,524 women and show germline variants predispose to mLOX and shape the magnitude of clonal expansion. medrxiv.org/content/10.110…

Super interesting talk coming up today at 17:15 in room 1.61-1.62 (level 1). Mattia Cordioli (Mattia Cordioli ) will present multi ancestry GWAS of COVID-19 and genetic connections to the sickness. Looking forward to see it!! #Genetics #ICHG2023 #COVID19 #GWAS

Now published in Nature Human Behaviour 🎉 🙏 for Tuomo Hartonen Brad Jermy leadership. The way to go: integrate health data, socio-economic info, and genetics The most comprehensive characterization of those who have and have not taken COVID-19 vax nature.com/articles/s4156… 🧵👇

Full summary statistics for our UKB-PPP GWAS of 1,463 circulating proteins are now available at synapse.org/#!Synapse:syn5… This includes full cohort (n=52,363), discovery (n=34,557), & African ancestry (n=931) analyses. More subpopulations (AMR, CSA, MID, EAS) available next week.

Aoxing Liu on population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular senescence #eshg2023

We are excited to share a pre-print of the flagship project of intervene_eu! medrxiv.org/content/10.110…

Very thrilled to formally introduce FinRegistry and Risteys - risteys.finregistry.fi But before getting into details. Do you know that any researcher in 🇪🇺can access FinRegistry data via Findata | Social and Health Data Permit Authority ? It is easy, secure, and under a clear legal framework academic.oup.com/ije/advance-ar…

Check out this thread about a new preprint from our lab 👇 Really interesting analyses by Andrius Vabalas on fairness of a DL-based mortality predictor

Really excited to share a new preprint📜, the main project I have been working on during my PhD! Why are people not adherent to their💊💊? How much do social vs genetic factors impact that? What about relevant pharmacogenes? Here’s what we found! (1/n) medrxiv.org/content/10.110…

Is the genetic of disease susceptibility and progression shared? We look at this question within a global biobank collaboration across 10 major diseases 💁

Hello #ASHG23! See 👇 the presentations from the team. Very proud of all the hard work that went into this. If anyone wants to chat about ML for EHR/registry data and integration with genetics, please DM. FinnGen FIMM HelsinkiUni

How do inherited factors summarized in polygenic risk scores (PRS) impact the risk of colorectal cancer? Our work now published British Journal of Cancer Brief highlights from the paper with Brad Jermy @adductor Samuli Ripatti Nina Mars and others! nature.com/articles/s4141… 🧵1/n

Our SBayesRC method is now published in Nature Genetics! SBayesRC is a full Bayesian method for polygenic score prediction that can analyse all common variants jointly with functional annotations in a single step. Zhili Zheng Institute for Molecular Bioscience nature.com/articles/s4158…

Our flaghsip intervene_eu paper is now published! I think this is an important piece of work to elevate the stature of polygenic score to that of other well-studied risk factors We provide country-specific cumulative incidence estimates for 18 diseases by PGS levels.

Our recent intervene_eu paper (Brad Jermy, Kristi Läll, & Wolford et al) has also been summarized for a more generalized audience. helsinki.fi/en/hilife-hels…

INTERVENE biobank analysts are installing the PGS Catalog Calculator at diverse biobanks and trusted research environments across the globe. The Calculator reproducibly calculates polygenic scores (PGS) and allows reporting of relative risk information. PGS Catalog 👇

When you finally have to let academia go…