Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
ashpublications.org/bloodadvances/…

our paper out today in ⁦Science Magazine⁩ showing how plasticity in early cancer progression influences cells’ ability to communicate w/ their environment! huge thank you & congrats ⁦Direna Alonso-Curbelo⁩ ⁦⁦Lowe Lab⁩ ⁦dana_peer⁩! science.org/doi/10.1126/sc…

⭐️Published in ⁦nature⁩ Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individual 🧬⁦naturePortfolio⁩ nature.com/articles/s4158…

Today our important study on air pollutants in the promotion of lung cancer has been published in nature led by Will Hill Emilia Lim Clare Weeden Swanton Lab ...Thread below🧵nature.com/articles/s4158…

BTG1 mutation yields supercompetitive B cells primed for malignant transformation science.org/doi/10.1126/sc…

TET2 mutations: causes #CHIP in hematopoietic stem cells but good for CAR-T therapy? Interesting study in nature provides mechanistic depth to 2018 case report
(rdcu.be/c5gTP) showing how TET2 disruption promotes CAR-T therapeutic efficacy
nature.com/articles/s4158…

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD biorxiv.org/content/10.110…

(1/2) Out now Nature Medicine! Read about our evolutionary landscape of Richter syndrome work in #collab with Dr. Cathy Wu’s lab Dana-Farber, also presented by Erin Parry, MD PhD at #ASH22 ! Leshchiner Lab @romainguieze @BroadInstitute #cll #lymphoma nature.com/articles/s4159…

Congratulations Emily Kolyvas, PhD!! 🎉

NIHOxCam NCI Center for Cancer Research CRUK Cambridge Institute

An incredible and badly needed resource for disease epigenetics. Complete methylomes for individual cell types purified from numerous human tissues and multiple individuals. Congrats Netanel,Judith, Ayelet, Ben,Yuval, Tommy + the rest of this amazing team!
nature.com/articles/s4158…

The SPOTS pre-print is now published Nature Biotechnology

Open: rdcu.be/c2DJe

Excited to integrate spatial dimensions in the study of somatic evolution.

Gratitude to shalev itzkovitz Andreas E. Moor for constructive review which motivated thorough added benchmarking

Thread 👇

Very excited to share our new study on determinants of resistance to anti-CD19 CAR T-cells (CART19) in large B-cell lymphomas (LBCLs)! Out today in Cancer Cell /1

cell.com/cancer-cell/fu…

I am very excited to share the latest pre-print from the Samantha Morris describing “CellTag-multi” a new multiomic single-cell lineage tracing method to simultaneously track clonal transcriptional and epigenomic states over time. Here are some highlights 🧵: biorxiv.org/content/10.110…

Just published in Science Magazine Science Magazine - A multivalent mRNA vaccine against all known influenza virus subtypes. Congratulations to all the researchers!!! Hensley Lab The Drew Weissman Lab Mohamad-Gabriel Alameh The Pardi Lab Penn Medicine
science.org/doi/10.1126/sc…

I am pleased to announce our latest paper.

We report results from single cell RNA and TCR sequencing, alongside spatial RNA and genome sequencing across different regions of kidney cancers:

cell.com/cancer-cell/fu…

I am so excited to share my first first-author paper, out today nature!!

So thankful to work with three other amazing first-authors Joel W. Blanchard Jose Davila Velderrain and Djuna von Maydell, and an inspiring team lead by Li-Huei Tsai 🤩🔥

nature.com/articles/s4158…

new out in Nature: nature.com/articles/s4158…

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab science.org/doi/10.1126/sc…

Excited to share our latest work (nature.com/articles/s4142…). We performed single-cell ATAC-seq in 5 mouse tissues during natural aging. We characterized the age-dependent changes in chromatin accessibility in 32 major cell types and link them to gene expression changes.

Excited to share our paper describing Numbat, a haplotype-aware CNV caller for scRNA-seq, out today on Nature Biotechnology!
nature.com/articles/s4158…
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