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Many immunologists ask me for a quick primer on neuroimmunology. This review by Keaton Song is a great way to dip your toe in the pool of the greatest biology of the next decade! academic.oup.com/jleukbio/artic…

A new blood biomarker for Alzheimer's disease accurately tracks Tau protein aggregate build up in the brain nature.com/articles/s4159…

Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo go.nature.com/3XFd81d

Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing dlvr.it/TKYCMC

Evolution-guided protein design of IscB for persistent epigenome editing in vivo go.nature.com/44XVBph

Just out nature Nasal vaccines for respiratory infections Best review I've seen on this important topic and a big unmet need nature.com/articles/s4158…

The landscape of RNA isoforms in human cortex is revealed by deep long-read RNA sequencing go.nature.com/3V8qEtq rdcu.be/ekKw6

IFN-γ chimeric autoantibody receptor T cells broadly deplete B cells autoreactive against interferon-γ science.org/doi/10.1126/sc… Science Immunology Cheng-Lung KU

This is an amazing paper from the groups of Anshul Kundaje (anshulkundaje@bluesky) & Scott Boyd and an example of how AI can be used well in biology. Basically, they are able to predict disease status (e.g. lupus, Covid, HIV, influenza) from BCRseq and TCRseq. I think this has great implications.

An antibody directed to the NAD-degrading enzyme CD38 in mice restores metabolic fitness, improves cognitive performance & lowers neuroinflammation nature.com/articles/s4146…

New research in Science establishes #CRISPR-associated transposase (CAST) as a powerful platform technology for efficient, RNA-guided gene integration in human cells. scim.ag/3FgKo93

90% of doing science is being open to new ideas.

An atlas of transcription factor-driven gene programs across human cells Teichlab biorxiv.org/content/10.110…

A new epigenetic clock —DNAmIC—outperforms others for identifying risk of all-cause mortality, and linked with lifestyle and immune system factors Nature Aging nature.com/articles/s4358…

The "reasoning doesn't exist" Apple paper drives me crazy. Take logic puzzle like Tower of Hanoi w/ 10s to 1000000s of moves to solve correctly. Check first step where an LLM makes mistake. Long problems aren't solved. Fewer thought tokens/early mistakes on longer problems. 1/11

How exercise protects the brain through neurovascular-associated astrocytes and neuroplasticity: Results of elegant single cell/nuceli studies in the experimental Alzheimer's model Nature Neuroscience nature.com/articles/s4159…

OpenAI quietly dropped a 34-page technical manual on building AI agents that 99% of people will never read. I spent 3 days coding every single pattern they revealed. Here's the practical guide to autonomous AI agents:🧵

Online Now! Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength dlvr.it/TLK9Q9 #stemcells

Nature research paper: Metabolic adaptations direct cell fate during tissue regeneration go.nature.com/3FMlpe4

Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a 🧵: