Learned something new today about cancer genetics from this paper. Counter-intuitive findings from a high throughput perturbation system - an oncogene doesn't always behave like an oncogene (and nor do tumor suppressors). Context matters!👇🏾

Truly seminal piece of work - in both implications on our understanding of cancer biology and the interdisciplinary methods by which we can interrogate it. Great job D2G Oncology team on advancing this work! #oncology #biotech

Woo! So proud of my D2G family, amazing to have this pre-print out on bioRxiv. Huge thanks to Lily Blair and the rest of our phenomenal team and collaborators for getting this across the finish line! A big step forward in our understanding of genetic interactions in lung cancer.

Exceptionally smart insights into cancer genetics courtesy of D2G Oncology's multiplexed, immunocompetent, autochthonous genetically engineered mouse platform.

Very proud of this work! I am going to write a longer thread but for now, check out the paper (biorxiv.org/content/10.110…) and the thread below. The fitness landscape of tumor suppression is complex and cannot be gleaned from simple linear idea of EGFR->KRAS->BRAF signaling 1/n

Very exciting to see such an elegant and informative study from D2G Oncology, where I recently joined the team, that employs a mouse model engineered by my graduate lab team Brian Dowland Maria Paz Zafra! Doesn't get better than that! Congrats to all involved 🥳 Lily Blair Ian Winters

Monte Winslow keynote #CRUKlung22 presenting his extraordinary insights into modelling lung cancers complexity and quantifying tumour initiation and growth w genetically engineered models and barcode sequencing ⁦CRUK Lung Centre⁩ meeting 2022

My fearless and great collaborator Monte Winslow's Lab is hitting it out of the park!

A blog post I contributed exploring how researchers are currently using bioRxiv to post non-traditional articles and opportunities for the future. Thanks ASAPbio for the support and for championing preprints!

Well, would you look at that! Another round of congrats to Alyna Katti Bianca Diaz and @cmcaragine on a fantastic review. Thanks to Nature Reviews Cancer and Anna Dart for the invitation to Neville Sanjana and I 😊

Completely agree especially with #1. We are at the very beginning though. Most people are treated with drugs given to all comers with low chance of success. We must find a way to do better and it is one of my life’s goals to help find a way to do much better. Monte Winslow's Lab #tubaseq

NEW review out today published with Springer Nature in Nature Reviews Cancer by our very own Jess Hebert American Cancer Society !! rdcu.be/dbfSR #Metastasis #MouseModels #Methods

Had a great time at #STATBreakthrough discussing current and future state of liquid biopsy tests with the companies at the forefront of a still nascent market. Thanks to Lizzy Lawrence for moderating!

Excited to share this labor of love from my grad work and our team Dow Lab Adrián Vega, PhD. I remember when I first targeted the mESCs and now it is a generalizable tool for programming point mutations in vivo and in organoids to engineer complex tumor models!

So proud of this work and Caroline Watson’s relentless hard work getting it together! Lots of mysteries we still don’t understand but amazing to me how well a simple model works in capturing the VAF distributions and the mutation rate and fitness insights that follow! 👇