Tomorrow at 1:15 PM CT, don’t miss my conversation with @NIHdirector Dr. Monica Bertagnolli and moderator Dr. Angela DeMichele Penn Medicine on how and where public investment will accelerate progress in oncology. #ASCO24

nice phase 2 trial on urachal adenoCa 1L Tx with modified FOLFIRINOX (+ G-CSF) showing ORR 62%, mPFS 9.3 months, mOS 20 months. Great to see trials in bladder Ca histology subtypes! ASCO #ASCO24 OncoAlert Ali Khaki Dimitra Bakaloudi MD, MS Bradley McGregor Shilpa Gupta Roger Li Hsieh Lab

Excellent talk by Tom Powles Uromigos on ctDNA in met urothelial Ca; ctDNA clearance more robust with chemo. Hypothesis-generating data; role of ctDNA needs to be further defined & included in trials designs as Tom said OncoAlert ASCO #ASCO24 Neeraj Agarwal, MD, FASCO Karine Tawagi MD

Very important point highlighted here by Pavlos Msaouel

🔶Please come and check our poster on ICI outcomes in pts with urothelial cancer and subtype histology #ASCO24 #Day3 Board number #275 ⏰9-12pm Petros Grivas Dimitrios (Dimitri) Makrakis Rafee Talukder Pedro C Barata, MD MSc FACP @JasoBrownMDPhD Ali Khaki Conquer Cancer, the ASCO Foundation ASCO University of Washington Fred Hutchinson Cancer Center

I’m honored and thrilled to chair the brilliant ⁦ASCO⁩ Evidence Based Medicine Committee charged to provide the highest quality clinical practice #ASCOGuidelines. An impressive group of volunteer experts and staff! Lotsa guidelines coming your way!

I’m at #ASCO24 right now. This list has been circulating. Yes, it is hard to find food at McCormick place. So I’m not condemning anyone who ventures into Pharma Disneyland to fill their stomachs. But, let’s at least pause for a moment to think about WHY these companies do this

What a privilege to serve as Chair with the awesome ASCO Guidelines staff and volunteers. The committee is in great hands with Beverly Moy and Eric Roeland, MD, FASCO, FAAHPM ! If you get the call to serve on a guideline, run, don’t walk! Evidence quality: High. Strength of recommendation: Strong.

EV plus pembro had amazing results in urothelial cancer and I’d use this drug for my own patients but Moon Landing? If we hype it like that as oncologists, how can we blame media? #ASCO24

I wish this was not controversial: If a trial 1. Enrolls in the US 2. Has explicit intention to seek regulatory approval in the US 3. Has control arm below US standard It is unethical- even if control arm is above local standard in poorer countries this trial enrolls in.

I thought this was a joke but it's real Mayo clinic offers unaccredited fellowships for people who've already completed heme onc training just to rob people of a year of attending salary. Extra fellowships are a scam don't be fooled. Just get a good job. If they really

Counting the dead in Gaza: difficult but essential - The Lancet “it is not implausible to estimate that up to 186 ,000 or even more deaths could be attributable to the current conflict in Gaza.” That is ~8% of the population of Gaza. thelancet.com/journals/lance…

American medicine teaches that nearly everything should be worked up, right away, but wisdom is learning what can be observed and worked up later, if and only if, it persists or worsens.

it’s so surreal Ukraine and Gaza are happening at the same time because we get to witness right before our eyes which children’s lives actually matter and which don’t

The more I practice clinical oncology and enroll patients on clinical trials I realize clinical trials do not represent real life. We need to stop being so selective. We want data that will actually inform clinical practice, not some idealistic version.

1. All too often these days, a single glitch results in a system-wide outage, affecting industries from healthcare and airlines to banks and auto-dealers. Millions of people and businesses pay the price. These incidents reveal how concentration can create fragile systems.

Find me a US presidential candidate who won’t murder our children. …

Netanyahu is a war criminal committing genocide against the Palestinian people. It is utterly disgraceful that leaders from both parties have invited him to address Congress. He should be arrested and sent to the International Criminal Court.

Fantastic session on IO in bladder Ca with many experts in the field! Intersection between immunotherapy & immunology! Excited to co-chair with Neelam Mukherjee great panel: Madhuri Koti Shilpa Gupta Shailender Bhatia, MD Brian Rini, MD Uromigos Stephanie Chisolm, PhD Ali Khaki Dr. Bishoy M. Faltas Dr. John Sfakianos

I am delighted to share our manuscript evaluating Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI) in pts with #Urothelialcancer treated with ICIs Thanks to our amazing team Petros Grivas Ali Khaki Rafee Talukder University of Washington Fred Hutchinson Cancer Center sciencedirect.com/science/articl… (1/7)