🔎 Conclusion

NECTIN4 amplifications serve as effective genomic predictors for both EV response and long-term survival in mUC patients.
🧐 Significance

This finding could guide personalized treatment strategies in mUC patients and potentially other cancers with NECTIN4…

📊 Results

High Frequency: NECTIN4 amplifications frequent in bladder cancer (17% in TCGA data; 26% in study cohorts).
Positive Response: 96% objective response rate in mUC-EV patients with NECTIN4 amplifications versus 32% in those without.
Survival Benefit: NECTIN4…

🔬 Materials and Methods

NECTIN4 FISH Assay: Developed to assess NECTIN4 copy number variations (CNVs) in a cohort of 108 mUC patients treated with EV (mUC-EV). This assay is straight forward and easy to implement for SOC - pathologies worldwide have experience with this kind of…

🔍 Purpose

Enfortumab Vedotin (EV), an anti-NECTIN4 antibody-drug conjugate, shows good efficacy in metastatic urothelial cancer (mUC).
NECTIN4 is located on chromosome 1q23.3.
This study aimed to evaluate NECTIN4 amplifications as a genomic biomarker for predicting EV response…

💫🌟Amazing Talk by Dana Rathkopf! 🌟 Managing low vs. high-volume prostate cancer in the NGI era:
Advanced Prostate Cancer Consensus Conference OncoAlert

🧬 Differences between oligometastatic HSPC in CIM vs PET
🔍 PET reveals fewer mutations, hints at better survival
🤔 Can PET-only be more indolent than…

I am visiting the world famous ⁦Gustave Roussy⁩ today! Amazing place!

We are happy to share our new study published today Journal of Clinical Oncology (👉 ascopubs.org/doi/10.1200/JC…) on the role of NECTIN4 amplifications to predict responses to Enfortumab Vedotin treatment in metastatic urothelial cancer.
With a huge contribution of our multinational team we uncovered…

Congratulations Julie Gralow very well deserved!

In lockstep with the ASCO Presidential Theme ASCOPres - Palliative Care is on the stage as a PLENARY at this year's Annual Meeting

This kind of research matters - has reach, clinical practice, and policy implications

meetings.asco.org/abstracts-pres…

other PC related orals I am looking fwd to

Areej El-Jawahri - Randomized trial of a multimodal intervention to enhance sexual function and quality of life (QOL) in hematopoietic stem cell transplant (HSCT) survivors meetings.asco.org/abstracts-pres…

Out in Journal of Clinical Oncology NECTIN4 Amplification predicts Enfortumab Vedotin response in Urothelial Cancer #mUC
💊 96% response rate to EV therapy in amplified cases vs 32% in others (P < .001).
➡️Perhaps we need to look deeper than IHC for other ADCs too? 🤔 ascopubs.org/doi/full/10.12…

💫🌟Michael J. Morris highlights at #APCCC24 the evolution of mHSPC monitoring 🧬:
OncoAlert Advanced Prostate Cancer Consensus Conference
1️⃣Radiographic progression can occur without PSA increases 📉

2️⃣Importance of regular imaging alongside PSA tests for accurate monitoring 🏥

3️⃣Survival outcomes differ…

🌟 #APCCC24 kicks off today in Lugano! 🌟

As we dive into an exhilarating day of insights and innovations in prostate cancer care, remember it's not too late to join us! Registration for online participation remains open, so seize the opportunity to be part of this pivotal…

Proud to be named an Advocacy Champion at the #ASCOAdvocacy Summit ! This past year I engaged with my local representatives to improve care for patients w #cancer . #ASCOAdvocacy  

At the 2024 #ASCOAdvocacy Summit , through our great society ASCO, we are urging #Congress to:

👉Help…

Brian Rini, MD Uromigos Tom Powles Nazli Dizman Toni Choueiri, MD Neeraj Agarwal, MD, FASCO 💙alison birtle Petros Grivas Rana McKay Tanya Dorff Matt Galsky “Maybe.”

Join Evan & me on Sat June 1 @asco for “tour de force” on ADCs in urothelial Ca!
Minas Economides, MD Arnab Basu Fuat Bicer MD, PhD DrTylerStewart Rohit Jain, MD Umang Swami Benjamin L Maughan MikaLion Giannis Mountzios Antonio Cigliola Valentina Tateo Jessica Hawley MD MS

lrn.peerview.com/150209297_1/15…

Seeing these pics reminds of the value & fun of #AACR24 . Great to connect with Biomarkers in the Post-TCGA era chair & 2023 American Cancer Society Researcher of the Year Dr. Lipika Goyal Stanford University, former ACS Research grantee Dr. Kimryn Rathmell & session speakers Petros Grivas & Dr. Singh.

⭐️American Academy of Rome, 🇮🇹 ! What a beautiful venue for a terrific meeting - Italian Summit of Precision Oncology. Super delighted to deliver a lecture in this historic venue.
Fantastic organization by the amazing the Presidents of the summit G Curigliano MD PhD Paolo Marchetti 👏🏼

Amazing Sumanta K. Pal, MD, FASCO Uromigos
#Uromigoscup #uromigoslive24 Tanya Dorff Tom Powles Brian Rini, MD
Will be ready to receive the cup in Seattle as the next stop :-)

A very brief visit to UCSF Fresno to deliver the Roger K. Larson Visiting Professor lecture. Was honored by the invitation from Dr. Uzair Chaudhary, who I met first through SCGCRC. Great morning spent with terrific faculty & fellows - coming home with lots of ideas for…