Very excited about these results. Congrats to Anna Rubinski and many thanks to BioFINDER for the great collaboration.

Join our virtual session on "Myelin changes and associated microglia activation as drivers of Alzheimer’s disease" today at 11.15 am PDT #AAIC2022 . Talks by A. Kohli from Bendlin Lab Dr. Constanze Depp Oskar Harari Oscar Harari and twitterless Mikael Simons @DZNE_en

The Alzheimer's Association appropriate use recommendations for blood biomarkers in AD were published today, and presented at #AAIC2022. They outline how BBMs can be used already today in the clinic and trials, and what additional studies are needed. bit.ly/3ONYhdJ

Very happy that our paper is now out in Alzheimer’s Research & Therapy where we show that higher levels of #myelin are associated with higher resistance against #tau pathology in #AlzheimersDisease. Many thanks to Michael Ewers Nico Franzmeier BioFINDER and others! alzres.biomedcentral.com/articles/10.11…

Just out in Nat Rev Neurology! With Morelia Monje Mora, Ankita Batra, Lucy Xu. We review key discoveries & remaining questions to understand how myelin plasticity supports normal function & becomes dysregulated in neurological diseases. Check it out! Stanford Neurology & Neurological Sciences nature.com/articles/s4158…

In this study published in Nature Aging: nature.com/articles/s4358… we measured sTREM2 and the DAM2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in the CSF of non-demented individuals, who underwent longitudinal amyloid-PET, tau-PET and cognitive assessment.

Please join this exciting session. We will start in about 30 min at 5.30 pm MEZ.

Time(s) to leave Twitter? nytimes.com/2022/12/15/tec…

We are hiring!! PhD/Post-doc in -Multimodal neuroimaging in Alzheimer’s disease -European consortium on imaging & blood markers -Collaboration on AI based image analysis. -Neurogenetics Check out isd-research.de/ewers-lab and apply now!

Our new paper shows polygenic risk score comprising 85 lead AD-risk SNPs to be associated with enhanced effect of amyloid on the rate of tau PET accumulation, and cognitive decline. Thanks to lead author Anna Rubinski & @rainermpg, Simon Frerich Nico Franzmeier tinyurl.com/576vd4um

We welcome U.S. FDA’s accelerated approval of lecanemab for treatment of the early stages of Alzheimer’s with confirmation of amyloid beta, and strongly renew our call for @CMSgov to cover FDA-approved Alzheimer’s treatments. Read our full statement:alz.org/news/2023/leca…

It's time for de Leon prizes for neuroimaging papers! (Self-)Nominate papers and/or join the voting committee! Deadline: March 13 Submit the best neuroimaging papers from 2022: alz.surveymonkey.com/r/JM5JPPK Join the voting committe: alz.surveymonkey.com/r/3XB6VLP

My hunch is this new lesion connectome-predictive modeling approach by Jiefeng Jiang published yesterday in Nature Communications will become the next generation of lesion network mapping. Seems very promising at this early stage. nature.com/articles/s4146…

Great start of AIC by year-in-review presented by Indira Turney. Shows importance of sex and racial differences in imaging markers of AD.#AAIC2023

New paper on connectomics, MAPT gene expression and amyoid PET to explain regional tau PET! tinyurl.com/22papw8x. Dovetails with our proposed model in Nature Rev Neurosci tinyurl.com/2vs8ah23. Special thanks to Lukai Zheng, Nico Franzmeier, BioFINDER, and Eli Lilly and Company

Please join this phantastic work shop in Philly before AAIC. There a still spots left!

Clearly a setback for patients and the research community in Europe. We need to encourage a well-informed decision process by doctors and patients rather than blocking access. Leqembi | European Medicines Agency ema.europa.eu/en/medicines/h…

Carolina Valentim presented our exciting finding of synaptic pathway-specific polygenic risk scores that enhance amyloid related tau-PET increases in AD - today at ADPD. #ADPD2025

Combining synaptic PET & tau PET, we reveal a dual role of synaptic density in regional susceptibility to tau and downstream degeneration in Alzheimer's. Brain, doi.org/10.1093/brain/…. Special thanks to first author Ying Luan, and collaborators Fang Xie and Binyin Li.

Luan et al. used dual PET imaging to examine the relationship between synaptic density and tau pathology in AD. They show that synapse-rich regions are prone to tau accumulation and that tau contributes to synaptic loss both locally and in connected areas. tinyurl.com/bdefth7e