Site of breast cancer metastasis is independent of single nutrient levels biorxiv.org/content/10.110… Very important work on metabolic dependencies of metastasis from the MVH Lab

I've seen enough: Francis Fukuyama has admitted defeat and declared The End of History to be over

and I don't just mean papers - I mean reagents, code, IP - everything

New preprint claims that most existing DNA language models perform just as well with random weights, suggesting that pretraining does nothing (Mistral & DNABERT-2 look like exceptions). We need better DNA language models.

I can’t believe it - after years of advocacy, exclusionary zoning has ended in Cambridge. We just passed the single most comprehensive rezoning in the US—legalizing multifamily housing up to 6 stories citywide in a Paris style Here’s the details 🧵

Seasonal depression “isn’t real” until you get a warm day in February and realize you’ve been dead inside for months

will forever point out that PhyloP, a traditional probabilistic model, has a fraction of the compute cost and does as well or better than many of these foundation models

Honoured to have been invited to this symposium! Had a great time presenting my work and interacting with other amazing students!

A case for substituting butter with plant oils From >220,000 participants in 3 large cohorts using validated food questionnaires with 33 years of follow-up jamanetwork.com/journals/jamai…

Recent Beamish award winner Tao Huan Nature Metabolism University of British Columbia describes how to avoid “nonsensical” results in metabolomics doi.org/10.1038/s42255…

im not a big gossip but i love Knowing Things. so when i ask for gossip it's never sinister. it's pure curiosity and a desire for knowledge

AHH!! My primary thesis work is finally out! Tweetorial to come...

If I'm reading the new STATE ( Adduri et al. , arcinstitute.org/manuscripts/St… ) paper correctly, we still cannot predict the effect of genetic perturbations better than a simple mean, and many methods do worse?

‼️Excited to share my first preprint in the Stegmaier lab – using metabolite depletion screens in physiological culture medium and in vitro/in vivo CRISPR screens, we identify metabolism of vitamin B2 (riboflavin) as a potent dependency in acute myeloid leukemia (AML). A 🧵…

calenderheads peep february 2026. you dont see em laid out like this often anymore. something to look forward to

Uh oh: deep learning models in genomics lose badly to very simple linear models. Could they have been over-hyped? (new paper by Simon Anders Constantin Ahlmann-Eltze (@const-ae.bsky.social) and Wolfgang Huber) nature.com/articles/s4159…

Happy to announce that I was awarded a pathway to independence award (K99) from the NCI/NIH today to work on studying whole-body metabolism driving cancer cachexia. None of this would be possible without support from Damon Runyon Cancer Research Foundation and mentorship from Eric N. Olson and mvhlab.

being the first to jaywalk is so aura inducing the other pedestrians all look at each other like damn he’s really him