Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells insight.jci.org/articles/view/… JCI insight Kathrin Held

Antigen avidity drives the durability of the vaccine immune response biorxiv.org/content/10.110…

Mucosal B cell memory selection integrates tissue-specific microbial cues via the IgA BCR biorxiv.org/content/10.110… #biorxiv_immuno

🧵(1/7) Proud that our new study is finally out after years of work! 🎉 Did you know even short-term #sleep loss 💤 can result in a molecular fingerprint linked to increased future #cardiovascular disease risk? 🫀 ❤️‍🩹 biomarkerres.biomedcentral.com/articles/10.11… Also timing & #exercise 🏃‍♂️ matter ->

Really cool preprint comparing mucosal sampling and IgA detection techniques for SARS-CoV-2 in three labs on two continents. With the Thalin, Gommerman an Simon labs. medrxiv.org/content/10.110…

Excited to share our new #OpenAccess review: "Maternal IgE Influence on Fetal and Infant Health" led by Jozef. We discuss how maternal #IgE shapes fetal immunity and the shift to intrinsic early-life IgE production, with implications for #allergy onset. 👉 doi.org/10.1111/imr.70…

Our study on CoVFit, an AI that predicts the fitness of SARS-CoV-2 from spike protein sequences, is now out in Nat Commun! CoVFit helps uncover viral evolutionary mechanisms, detect emerging variants, and forecast viral evolution! nature.com/articles/s4146…

Published today📣 Our nasal booster in the "Prime & Spike" vaccine works without adjuvants (which are needed to induce adaptive immunity but also cause inflammation). Dong-il Kwon 🇰🇷 Tianyang Mao Benjamin Israelow et al. asked how this is possible. (1/) nature.com/articles/s4159…

A novel low-volume multiplex immunofluorescence assay was developed to simultaneously measure all nine antibody isotypes and subtypes in human fluids, including breastmilk. Learn more about the method in The JI: ow.ly/nAJ450VWjh8

Our work on new ways to identify broad-spectrum neutralizing antibodies against future SARS-CoV-2 variants is finally out Nature Microbiology! In this paper, we described a novel bnAb identification strategy based on accurate viral mutation hotspot prediction.

Online now: Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota dlvr.it/TLZYbj

Babies born by cesarean section don’t get the rich blend of microbes that come from a vaginal birth—microbes that may help prevent disorders such as asthma and allergies. Research from 2020 suggests a way to change that. #WorldMicrobiomeDay scim.ag/3T6iShX

👩‍🔬 Chung Lab is looking a new Research Assistant to explore how IgA antibodies distribute and affect mucosal immunity in mice 🧐🐁🐁 More details ⬇️ unimelb.wd105.myworkdayjobs.com/en-US/UOM_Exte…

Our work on responses to COVID-19 vaccine in vulnerable populations continues. Here we show older individuals generate a lower non neutralising antibody response (ADCC) post dose 6 that correlates with lower levels of IgG1 -known to primarily mediate ADCC. nature.com/articles/s4154…

🚨 New paper alert! 🚨 Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to Open Philanthropy for funding this work! bit.ly/4lgr0rM

Excited to share our latest paper @NatureMethods We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). nature.com/articles/s4159…

A cost-effective ultra-high-throughput cytometry-based framework for the detection of physical interactions between cells, along with the characterization of complex cellular landscapes Nature Methods nature.com/articles/s4159… nature.com/articles/s4159…

mRNA-, adenovirus vector-, and protein-based #COVID19 #vaccines have distinct effects on lymph node stromal cell gene expression and function, according to new research in mice. Research group of Professor Marko Salmi Learn more in Science #Immunology: scim.ag/4oHFi7Q

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and ... biorxiv.org/content/10.110… #biorxiv_immuno

In new study led by Bernadeta Dadonaite, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. biorxiv.org/content/10.110…