The best update of VSCode since I started using it. Really good!

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Yesterday, our clinical blood biomarker study, CliPAD, conducted at the University of Pittsburgh and UPMC, was featured on NBC’s WPXI news. Take a look at our segment! We are thankful to @wpxi @alzgpa and the UPMC media team for helping with this feature. Information on the

Tremendous effort by Guilherme Povala Tharick Pascoal working with many others to harmonize tau PET. Some upfront work needed by users and independent evaluation underway, but check out their visual calculator they made unitau.app Really looking forward to the

Thank you for the support, Prof. Melissa E. Murray 📸🔬.

Thank you Dana for always supporting us!

In Nature Medicine, we show: 1. P-tau262 & P-tau356 as markers of pre-tangle tau pathology; 2. Identify a core region that defines soluble tau assemblies (STA); and 3. Validate CSF STA assay in autopsy & tau PET cohorts. Congrats to all coauthors! nature.com/articles/s4159…

It was a tremendous honor to host the first AAIC Neuroscience Next Hub held in Pennsylvania at the University of Pittsburgh on Monday, as part of the 2025 edition of this global conference! We are immensely grateful to our all attendees, both in person and online, who

Very happy to share that our paper linking genetic risk for ADHD to more severe dementia is out! Thank you Douglas Leffa for the trust in this project, and Tharick Pascoal for the guidance.

🎉Exciting news! We’re proud to have 2 of our papers ranked among the top 10% most-viewed in 2023 in Alzheimer's & Dementia Journals Alzheimer's Association 🔗Plasma p-tau231 & p-tau217: alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… 🔗BBB integrity & use of plasma Aβ: alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Well deserved! Congratulations Caru! 👏👏👏

New from our lab! 🧪✨ Pascoal Lab Led by my brilliant co-supervisor Bruna Bellaver, this study shows that plasma GFAP can help enrich clinical trials in preclinical Alzheimer’s disease—cutting costs by up to 64% and identifying those most likely to show tau progression.

Douglas, my friend. This is so nice! You deserve it. Congratulations. 🎉

Congrats, Bruna! Very nice paper. Glad to be part of it. 😁

Congratulations!!!

Down Syndrome (DS) is associated with early-onset Alzheimers disease (AD) and sometimes considered a genetic form of AD. Our recent published paper explores neuroinflammation in the aging process of AD with PET. dx.doi.org/10.1002/alz.70… Alzheimer's Association

New paper alert🚨 Our new study led by Dr Fran Nature Communications showed glial reactivity correlates with synaptic dysfunction in aging and AD, revealing how astrocyte and microglial activation influence synaptic degeneration. Check it now: nature.com/articles/s4146…

An amazing week in 🇫🇷, surrounded by inspiring science, dear friends, and long-time collaborators. Taking part in FBEM was a truly special and rewarding experience. Many thanks to the organizing committee for the warm welcome, especially Anne-Karine Bouzier-Sore. See you soon in 🇧🇷!

Heading to #AAIC2025? We’re excited to share 9 oral presentations and 16 posters at this year’s conference! Come find us - we’d love to connect, discuss, and explore opportunities for collaboration.👇

We are delighted to present our new blood-based p-tau217 biomarker assay developed in the Karikari Lab at the University of Pittsburgh!!!🎉. In addition to analytical validation, we benchmarked the performance of the new method against commercial p-tau217, showing similar