Exercise leads to the release of myokines, increasing neuron growth by 4x. 🧵1/10

Delighted to share our new study, led by @annacgeraghty and Lehi Acosta , uncovering the cellular dysregulation underpinning cognitive impairment after CAR T cell therapy and a strategy to rescue this cellular and cognitive dysfunction in mice. 1/ cell.com/cell/fulltext/…

The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 Journal of Clinical Investigation jci.org/articles/view/…

Why do some people who have mutations of familial Alzheimer's do not get the disease? They have protective genomic variants. A first-rate review The Lancet Neurology thelancet.com/journals/laneu…

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer’s disease dlvr.it/TMP4sn

The word of the week is lithium. Here are my words about it!

Neuro–immune crosstalk: focus on innate lymphoid cells dlvr.it/TMTtmH

Exercise and the Organ-Brain Axis: Regulation of Neurological Disorders by Emerging Exerkines sciencedirect.com/science/articl…

Online now: Microglia regulate neuronal activity via structural remodeling of astrocytes dlvr.it/TMZKf2

Maternal stress triggers early-life eczema through fetal mast cell programming. nature nature.com/articles/s4158…

Exercise workload: a key determinant of immune health – a narrative review pmc.ncbi.nlm.nih.gov/articles/PMC12…

Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism Neuron cell.com/neuron/fulltex…

Bone-muscle crosstalk under physiological and pathological conditions link.springer.com/article/10.100…

Most neurons are excitatory, but some do the opposite and dampen the activity of other neurons. In this visualization by our Electron Microscopy team, an axon (red) sneaks its way in between a satellite microglia (blue) and an inhibitory neuron (gray).

🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. Prof. Melissa E. Murray 📸🔬 authors.elsevier.com/a/1lxn85FFzL...

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice nature.com/articles/s4146…

We are pleased to share our newest publication from the Blurton-Jones Lab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" sciencedirect.com/science/articl…

Compared with APOE4, a risk allele for Alzheimer's disease, how do protective variants like APOE2 work? Neuron cell.com/neuron/fulltex…

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins Nature Neuroscience nature.com/articles/s4159…

Targeting immune cells with an engineered IL-10 variant rebalances inflammatory programs in microglia, improves neurogenesis, and enhances cognition in old mice Immunity Paloma Navarro Brunet Lab Stanford University cell.com/immunity/fullt…